An important function of our cells’ signaling pathways is to coordinate growth with environmental cues, such as the availability of nutrients in the cell’s environment. Cell growth plays an important role in normal cell function—for example, building muscle in response to exercise— and it also goes awry in diseases such as cancer. The protein complex GATOR2 plays an important role…
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Patients with heart disease are at risk of experiencing a potentially lethal “electrical storm” involving recurrent episodes of a type of irregular heartbeat called ventricular tachycardia (VT). Electric shock therapy is used to treat VT following a heart attack, but unfortunately, options to prevent its recurrence are limited.
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Broad Institute of MIT and Harvard has named Erin Chen, a dermatologist and microbiologist, and Sam Peng, a biophysicist and physical chemist with expertise in single-molecule imaging, as core institute members. Chen will join in January 2023 and will also serve as an assistant professor in the Department of Biology at MIT and an attending dermatologist at Massachusetts General Hospital. Peng joined…
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Clinical studies have demonstrated a strong association between Alzheimer’s disease (AD) and delirium. A change to the Tau protein, which can lead to the formation of tangles in brain, is one of the hallmarks of AD pathology, and Tau phosphorylation at threonine 217 (Tau-PT217) and threonine 181 (Tau-PT181) are new plasma biomarkers that can detect early-stage AD. A clinical study…
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It takes a lot of time—and money—to diagnose Alzheimer’s disease. After running lengthy in-person neuropsychological exams, clinicians have to transcribe, review, and analyze every response in detail. But researchers at Boston University have developed a new tool that could automate the process and eventually allow it to move online. Their machine learning–powered computational model can detect cognitive impairment from audio…
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Differences in behavior among people with Autism Spectrum Disorder, or ASD, are closely related to differences in neuroanatomy—the shape of a brain—a team of Boston College neuroscientists report in a recent issue of the journal Science. This discovery could help to understand the causes of ASD, and to develop personalized interventions. The team used artificial intelligence to study magnetic resonance imaging data from over 1,000 individuals…
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Thanks to advances in genomics in recent decades, researchers now know the genetic mutations responsible for many diseases. However, researchers often still do not know how the mutation leads to the disease—what it changes inside of cells to cause symptoms. Figuring out this missing piece, the disease mechanism, not only advances understanding of the disease but can be essential for…
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Using four unrelated strains of the microscopic nematode C. elegans originating from different parts of the world, a group of worm biologists have developed a model system to study individual differences in metabolism. The use of C. elegans, a widely studied model organism, allowed the team to study the unique and complex interplay between genetics, diet, microbiota and other environmental factors that can…
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