The Broad Institute of MIT and Harvard today announced a new research alliance with Novo Nordisk aimed at addressing critical unmet clinical needs in diabetes and cardiometabolic diseases. The collaboration will focus on advancing three programs over the next three years. Two programs aim to identify drug targets for clinically important subtypes of type 2 diabetes, which affects more than…
Dr. Chun Lim discusses how BIDMC will be the first MA hospital to provide lecanemab to patients and the importance of the medical milestone An estimated 6.7 million adults in the U.S. are diagnosed with Alzheimer’s disease, an irreversible, progressive brain disorder that slowly destroys memory, cognitive skills, and eventually the ability to carry out simple tasks. Alzheimer’s disease, which…
Prime editing technologies allow scientists to precisely edit the genome in a variety of ways and could one day be used to treat genetic diseases. Now researchers at the Broad Institute of MIT and Harvard have used cutting-edge continuous laboratory evolution and engineering methods to develop improved versions of the gene-editing tool. Their new editors are more efficient and specialized…
To understand the full relationship between brain activity and behavior, scientists have needed a way to map this relationship for all of the neurons across a whole brain — a so far insurmountable challenge. But after inventing new technologies and methods for the purpose, a team of scientists in The Picower Institute for Learning and Memory at MIT has produced…
A new agent that subverts myeloma cells from within while also subjecting them to an immune system attack produced impressive responses in combination with dexamethasone in patients with multiple myeloma that had relapsed and stopped responding to all currently available therapies, a clinical trial conducted by researchers at Dana-Farber Cancer Institute and around the world has found. Results of the…
After a national search, the MIT Office of the Vice Chancellor has named Denzil A. Streete senior associate dean and director of the Office of Graduate Education (OGE). Streete succeeds Blanche Staton, who retired this summer after serving for more than 25 years at MIT. He will begin his role at MIT on Sept. 12. Streete brings significant experience as…
Genetic detective work by Brigham researchers offers insight into a novel therapeutic approach for treating Alzheimer’s disease Alzheimer’s disease (AD) varies widely in its age of onset, presentation and severity. Recently, the SORL1 gene has received increased attention since variations in this gene have been associated with both early and late onset AD. However, little is known about how damage…
Treating children with epilepsy has traditionally been a matter of trial and error, trying different drugs one after the other. In the one-third of patients for whom the drugs do not work and seizures continue, doctors consider brain surgery — if it can be done safely. Early in her career, Ann Poduri, MD, MPH, who directs the Neurogenetics and Epilepsy…
Figuring out how hundreds of different kinds of brain cells develop from their unique expression of thousands of genes promises to not only advance understanding of how the brain works in health, but also what goes wrong in disease. A new MIT study that precisely probes this “molecular logic” in two neuron types of the Drosophila fruit fly shows that…
A novel antibody-drug conjugate continues to demonstrate superior benefit for patients with HR+, HER2- metastatic breast cancer when compared to standard chemotherapy, according to a new study in The Lancet. In the second planned analysis of data from the Phase 3 TROPiCS-02 clinical trial, published today, investigators report that sacituzumab govitecan produced a statistically significant improvement in overall survival compared to…