Tendon injuries can happen in an instant. With a loud pop and a sharp pain, even the most casual athlete’s lifestyle can be altered permanently. Jeff Ruberti, professor of bioengineering at Northeastern, learned this unfortunate lesson firsthand: While playing pickup soccer at a conference in 2017, he planted his foot to change directions, and instantly snapped his Achilles tendon. “You…
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Whitehead Institute team finds drugs that activate a key brain gene; initial tests in cells and mice show promise for rare, untreatable neurodevelopmental disorder. A research team led by Whitehead Institute scientists has identified 30 distinct chemical compounds — 20 of which are drugs undergoing clinical trial or have already been approved by the FDA — that boost the protein…
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Biogen, headquartered in Cambridge, Massachusetts, and Alkermes, based in Dublin, announced positive topline data from EVOLVE-MS-2, a Phase III trial of diroximel fumarate for relapsing-remitting multiple sclerosis (RRMS) compared to Tecfidera (dimethyl fumarate). Biogen and Alkermes inked a global license and collaboration deal in 2017 to develop and commercialize ALKS 8700 for relapsing forms of multiple sclerosis (MS). ALKS 8700, diroximel fumarate, is a novel,…
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Life science real-estate development firm Alexandria Real Estate Equities expects that it could develop an up to 650,000-square-foot campus at 5, 10 and 15 Necco St. in Boston’s Fort Point neighborhood, with construction possibly starting early next year on a lab property next to the future world headquarters of General Electric Co. Peter Moglia, the co-CEO and co-chief investment officer…
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Gel cushion used to elevate polyps during endoscopy could reduce the risk of tearing the colon lining. More than 15 million colonoscopies are performed in the United States every year, and in at least 20 percent of those, gastroenterologists end up removing precancerous growths from the colon. Eliminating these early-stage lesions, known as polyps, is the best way to prevent…
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WASHINGTON, July 30, 2019 /PRNewswire/ — U.S. News & World Report, the global authority in hospital rankings, today released the 2019-20 Best Hospitals rankings. The new and revised 30th edition provides a multifaceted assessment on nearly every hospital nationwide that is designed to assist patients and their doctors in making informed decisions about where to seek care. This year, U.S. News updated the methodology in…
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This study not only solves the problem of cell separation in the laboratory, but helps improve understanding of how type 2 diabetes progresses as a disease. BOSTON – (July 29, 2019) – Researchers at Joslin Diabetes Center, an affiliate of Harvard Medical School, have unlocked the key to clearly identifying diseased beta cells in type 2 diabetes. This discovery has…
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Mike Levin studies how cells make collective decisions about growth and shape using bioelectricity At first glance, Mike Levin’s lab looks like any standard biology lab with its shelves of petri dishes containing small, brown, semitransparent flatworms called planaria, one of the organisms his lab studies. Look more closely at the bodies of the tiny worms swimming and stretching under the…
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Tufts researchers discover a gene necessary for maintenance of healthy sleep in fruit flies, which might help understand human sleep. What keeps us awake—and helps us fall asleep? The answer is complex, but involves what are called circadian rhythms, which are found in all species with sleep-wake cycles—physical, mental, and behavioral changes that follow a regular schedule. In most animals,…
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A method combining two distinct immune system-based treatments may help to improve outcomes for patients with glioblastomas and other solid tumors. BOSTON – Building on their research showing that an exciting new form of immunotherapy for cancer has activity in patients with glioblastoma, the most common and most deadly form of brain cancer, Massachusetts General Hospital (MGH) investigators have created…
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