A novel antibody-drug conjugate continues to demonstrate superior benefit for patients with HR+, HER2- metastatic breast cancer when compared to standard chemotherapy, according to a new study in The Lancet.
In the second planned analysis of data from the Phase 3 TROPiCS-02 clinical trial, published today, investigators report that sacituzumab govitecan produced a statistically significant improvement in overall survival compared to chemotherapy. The overall survival for patients taking part in the global study was 14.4 months for those who received sacituzumab govitecan and 11.2 months for those given chemotherapy. The sacituzumab group also showed superior response rates as well as prolonged median progression-free survival when compared to standard chemotherapy. Patients treated with sacituzumab had a 34% lower risk of cancer progression or death than those treated with chemotherapy.
