Break Through Cancer today announced its formal launch as a public foundation designed to find new solutions to the most intractable challenges in cancer. The foundation is being launched with an extraordinary challenge pledge of $250 million from Mr. and Mrs. William H. Goodwin, Jr. and their family, and the estate of William Hunter Goodwin III. This represents one of the largest gifts ever in support of cancer research. Led by Dr. Tyler Jacks the David H. Koch Professor of Biology and Director of the Koch Institute for Integrative Cancer Research at MIT, Break Through Cancer will fund and support collaborative research teams drawn from several of the country’s top cancer centers.