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Migraine Prevention in Children and Teens: Weak Support for Medication

By February 14, 2020No Comments

everal medications successfully treat an active migraine. But a review of the medical literature from Boston Children’s Hospital finds only weak evidence that drug treatment prevents migraine in children and adolescents. Only two medications — topiramate and propranolol — showed any difference in preventing migraine in this age group compared with a placebo.

photo of Joe Kossowsky
Joe Kossowsky (Jacob Murphy)

The authors reviewed 23 clinical studies of medications used for migraine prevention in children and adolescents. Altogether, nearly 1,700 patients received an active drug, while about 520 patients received a placebo. Very few trials found a difference in migraine prevention between drug and placebo. The review was published in a paper in JAMA Pediatrics.

In this Q&A, co-first author of the paper, Joe Kossowsky, PhD, MMSC, of the Department of Anesthesia, Critical Care, and Pain Medicine at Boston Children’s, discusses highlights of the study.