Sachin Bhagchandani, a graduate student in the Department of Chemical Engineering currently working at the Koch Institute for Integrative Cancer Research, has won the National Cancer Institute Predoctoral to Postdoctoral Fellow Transition (F99/K00) Award. Bhagchandani is the first student at MIT to receive the award. The fellowship is given to outstanding graduate students with high potential and interest in becoming…
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Samuel, Zhen, and Venkatachalam Labs Observe C. elegans Brain in Action

Small transparent animals like zebrafish and C. elegans have long been heralded for their accessibility to optical methods to manipulate and monitor neuronal function. A major shift in these approaches occurred when fast microscopes and efficient data analysis began to allow whole-brain imaging. Several years ago, researchers in Aravi Samuel’s lab and their collaborators started building the tools needed for whole-brain imaging in C. elegans.…
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Joseph P. Mizgerd, ScD, was named the inaugural Jerome S. Brody, MD, Professor of Pulmonary Medicine in a ceremony held both in-person and over Zoom. On Sept. 14, colleagues, friends and family gathered to witness the installation and celebrate his contributions to the pulmonary field. Mizgerd is Director of the Boston University Pulmonary Center and professor of medicine, microbiology and…
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Five Dana-Farber Cancer Institute faculty members are inductees of the 2021 Giants of Cancer Care® program. Toni Choueiri, MD, Pasi Jänne, MD, PhD, Matthew Meyerson, MD, PhD, Paul Richardson, MD, and Richard Stone, MD, are among the 14 inductees selected to join the prestigious 2021 class. Dr. Choueiri is the Director of the Lank Center for Genitourinary Oncology at Dana-Farber Brigham Cancer Center and the Co-Leader of…
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Deep Learning Helps Predict New Drug Combinations to Fight COVID-19

The existential threat of COVID-19 has highlighted an acute need to develop working therapeutics against emerging health threats. One of the luxuries deep learning has afforded us is the ability to modify the landscape as it unfolds — so long as we can keep up with the viral threat, and access the right data. As with all new medical maladies,…
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Research Roundup: September 17, 2021

Welcome to the September 17, 2021 installment of Research Roundup, a recurring snapshot of recent studies published by scientists at the Broad Institute and their collaborators. Identifying causal variants in noncoding regions of the genome Genetic variations in the 3′ untranslated region (UTR), a noncoding area of mRNA that influences gene expression, are strongly associated with human traits and diseases but…
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Over the past decade, scientists have been exploring vaccination as a way to help fight cancer. These experimental cancer vaccines are designed to stimulate the body’s own immune system to destroy a tumor, by injecting fragments of cancer proteins found on the tumor. So far, none of these vaccines have been approved by the FDA, but some have shown promise…
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Immune Escape

Cancers in different tissue types develop unique genetic mechanisms to avoid discovery and destruction by the immune system, suggests a new study in mice by scientists at Harvard Medical School, Brigham and Women’s Hospital, and Dana-Farber Cancer Center. The findings, published Sept. 17 in Science, could explain why some cancer types respond to current immunotherapies while others don’t—laying the foundation for researchers to…
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Despite breakthrough treatments for high-grade serous ovarian cancer, about 80 percent of patients relapse within two years, often resistant to treatment. The good news is that Dana-Farber scientists are pursuing multiple avenues of research that very well may improve outcomes. “A number of patients develop progressive disease at a later point, potentially indicating that a subset of the cells were…
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Awards & Recognitions: September 2021

Three HMS researchers are among 13 leading endocrinologists chosen by the Endocrine Society as winners of its 2022 Laureate Awards, which will be presented at the organization’s annual meeting. The Endocrine Society’s 2022 Laureate Award winners from HMS are: Henry Kronenberg, HMS professor of medicine at Mass General, was named to receive the Fred Conrad Koch Lifetime Achievement Award, which recognizes lifetime achievements and exceptional contributions…
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