Symposium Overview

Session I: Neurophysiology

•   Spinal cord injury in a dish
•   Synapse imaging: assessment of drug selection and efficacy
•   Histoneurology: IHC staining and analysis of neurological diseases
•   Patch clamp method for drug screening

Session II: Quantitative Output for Neurodegenerative Diseases Using in vivo Electrophysiology

• Application of Electrophysiology as an endpoint in EAE Multiple Sclerosis studies

Session III: Pig Models of Pain

• Post-operative pain
• Modified post-operative pain
• Neuropathic pain

Meet The Speakers

Sigal Meilin, PhD, Chief Scientific Officer

Dr. Meilin’s passion over 25 years has been in the understanding of neuro-degeneration and pain processes. Her research focus has been on exploring and creating true models of pain including translational models in pigs which closely mimic and forecast drug activity in humans. The MD Biosciences Innovalora laboratories, under the scientific leadership of Sigal Meilin, have become leaders in the discovery and validation of novel pathways and new candidate drugs. Sigal Meilin holds a PhD from Bar Ilan University in Tel Aviv, Israel where she also continued her research involving multi-parametric monitoring of the living brain under oxygen stress and the cross talk between the immune system and the neuronal system in neurodegenerative disease. She was the leader of the pharmacology department of Pharmos, Ltd, prior to joining MD Biosciences in 2006.

Yoav Shulman, PhD, Neurophysiology Laboratory Manager

Dr. Shulman leads the neurophysiology and electrophysiology laboratories at MD Biosciences Innovalora. His primary focus is on method development and validation as well as execution of sponsor studies together with his team. Prior to joining MD Biosciences Innovalora, Yoav completed his doctoral work at the Ben Gurion University of the Negev followed by a post-doctoral research at the Technion in Haifa, Israel. Specialties include the establishment of spinal cord injury model using primary cultures from adult rat spine and peripheral nerve injury model using primary cultures from adult rat DRG. Other experiences include the establishment of an electrophysiology system for pharmacology assays using primary hippocampal cultures (Orenbuch et al. 2012), live Ca²ꜙ imaging and electrophysiology on ex-vivo brain slices (Sandler et al. 2016), live protein expression and movement, identifying novel protein-protein interactions using a wide array of technologies (Shulman et al. 2015), Brain stem slices and electrophysiology measurements for ionic channel identification (Safori et al. 2015) and live EMPs, SSEPs, EEG and EMG for monitoring human brain and spine procedures in OR.