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Stay up-to-date with all of the life science events taking place in the Greater Boston area with the Science in Boston events calendar! From academia to industry and biotech to pharma, our events calendar is your complete source for life science conferences, symposiums, networking, and workshops in Boston. We even cover science pub nights and science fundraisers!

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Glial and Neuronal Biology of the Aging Brain Symposium

October 5, 2022 - 1:00 pm - October 6, 2022 - 1:15 pm


Join us for a joint Alana Down Syndrome Center and Aging Brain Initiative symposium on October 5-6, 2022. The topic this year will be Glial and Neuronal Biology of the Aging Brain.

This event will take place virtually over the course of two days: October 5 and October 6. Talks will begin at 1:00pm ET on October 5 and 9:00am ET on October 6 . The October 6 talks will be followed by a virtual poster session beginning at 12:15pm ET.


The Aging Brain Initiative and The Alana Down Syndrome Center
The Aging Brain Initiative (ABI) is an interdisciplinary effort by MIT focusing on understanding neurodegeneration and discovery efforts to find hallmarks of aging, both in health and disease.

The Alana Down Syndrome Center (ADSC) aims to deepen knowledge about Down syndrome and to improve health, autonomy and inclusion of people with this genetic condition.

The ABI and the ADSC have joined forces for this year’s symposium to highlight how aging-related changes to the brain overlap with neurological aspects of Down syndrome. Our hope is to encourage greater collaboration between the brain aging and Down syndrome research communities


This will be a virtual event viewable via webcast.

All registrants will be sent the webcast link via email one week prior to the event (with reminders the day prior and morning of the event). Please keep in mind that emails will be sent to the email address you use to register.

Wednesday, October 5 | Moderator: Ravikiran Raju, Picower Institute, MIT, Boston Children’s Hospital

1:00-1:10pm: Opening Remarks, Li-Huei Tsai, Director, Picower Institute, MIT, Lead Investigator, Aging Brain Initiative, Director, Alana Down Syndrome Center
1:10-1:40pm: Beth Stevens, Boston Children’s Hospital, Harvard Medical School
1:40-2:10pm: Li Gan, Weill Cornell Medical College
2:10-2:40pm: Tracy Young-Pearse, Brigham and Women’s Hospital, Harvard Medical School , “APP and DYRK1A regulate axonal and synaptic vesicle protein networks and mediate Alzheimer’s pathology in trisomy 21 neurons”
2:40-3:00pm: Break
3:00-3:30pm: Elizabeth Head, University of California, Irvine, “Cerebrovascular Pathology as a Function of Age and Alzheimer disease in Down syndrome”
3:30-4:00pm: Gilbert Di Paolo, Denali Therapeutics, “Lysosomal Functions of Progranulin and Implications for Treatment of Frontotemporal Dementia”
4:00-4:05pm: Closing Remarks

Thursday, October 6 | Moderator: TBA

9:00-9:10: Opening Remarks
9:10-9:40am: Nancy Yuk-Yu Ip, The Hong Kong University of Science and Technology, “Understanding Innate Immunity in Alzheimer’s Disease – Insights for the Development of Therapeutics”
9:40-10:10am: Michael Heneka, Luxembourg Centre for Systems Biomedicine (LCSB)
10:10-10:40am: Shane Liddelow, NYU, “Reactive Astrocyte Responses to Inflammation and Neurodegeneration”
10:40-11:00am: Break
11:00-11:30am: Myriam Heiman, Picower Institute, MIT, “Single-cell Dissection of the Human Cerebrovasculature in Health and Disease”
11:30am-12:00pm: Adam M. Brickman, Columbia University
12:00-12:05pm: Closing Remarks
12:05-12:15pm: Break/Poster Session Set-up
12:15-1:15pm: Virtual Poster Session (held on Aimeet)


October 5, 2022 - 1:00 pm
October 6, 2022 - 1:15 pm