Science Events in Boston
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Dana Farber Targeted Protein Degradation Seminar
December 3, 2020 - 12:00 pm - 1:00 pm
Small-molecule-induced protein polymerization
Mikolaj Slabicki, Hojong Yoon, Jonas Koeppel
December 3rd, 2020
Webinar registration:
https://dfci.zoom.us/webinar/register/WN_rOAQV4c8Tge2bXW23l9rYQ
Host: Katherine Donovan
Researchers from the Ebert and Fischer lab teamed up to solve the elusive mechanism of a BCL6 degrader, BI-3802. By employing functional screens, biochemical dissection, and structural characterization, they identified that BI-3802 induces BCL6 polymerization, which triggers proteasomal degradation of BCL6. The seminar will be presented by Mikolaj Slabicki (Ebert Lab), Hojong Yoon (Fischer Lab), and Jonas Koeppel (Ebert Lab).
