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Dana Farber Targeted Protein Degradation Seminar
January 21, 2021
Brenda Schulman is a Director at the Max Planck Institute of Biochemistry. She is broadly interested in how ubiquitin and ubiquitin-like proteins are matched with specific substrates, and how they alter the functions of their targets to regulate the cell cycle, autophagy, metabolic signaling, differentiation and other biological processes. Her lab structurally visualizes transient ubiquitylation complexes trapped as if in action, biochemically reconstitutes signaling pathways, develops chemical tools to probe ubiquitin signaling, and employs cell biology to investigate how ubiquitylation mediates regulation. Schulman is an elected member of American Academy of Arts and Sciences, the National Academy of Sciences, EMBO, and the German National Academy Leopoldina, and has been recognized by awards including most recently the Gottfried Wilhelm Leibniz Prize and Ernst Jung Prize for Medicine.