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BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20210302T160000
DTEND;TZID=America/Vancouver:20210302T170000
DTSTAMP:20260404T010918
CREATED:20210301T175919Z
LAST-MODIFIED:20210301T175919Z
UID:13122-1614700800-1614704400@scienceinboston.com
SUMMARY:Biology Colloquium Series
DESCRIPTION:Speaker: Dr. Uri Alon\, Weizmann Institute. \nHosted by: Pulin Li. \nTitle: “Mathematical Essence of Aging.” \nThe Biology Colloquium is a weekly seminar held throughout the academic year\, featuring distinguished speakers in many areas of the biological sciences\, from universities and institutions worldwide. More information on speakers\, their affiliations\, and titles of their talks will be added as available. The Colloquium will zoom at 4:00PM  Tuesdays during the school year. Contact: Linda Earle lkn@mit.edu
URL:https://scienceinboston.com/event/biology-colloquium-series/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20210302T160000
DTEND;TZID=America/Vancouver:20210302T170000
DTSTAMP:20260404T010918
CREATED:20210301T175919Z
LAST-MODIFIED:20210301T175919Z
UID:27658-1614700800-1614704400@scienceinboston.com
SUMMARY:Biology Colloquium Series
DESCRIPTION:Speaker: Dr. Uri Alon\, Weizmann Institute. \nHosted by: Pulin Li. \nTitle: “Mathematical Essence of Aging.” \nThe Biology Colloquium is a weekly seminar held throughout the academic year\, featuring distinguished speakers in many areas of the biological sciences\, from universities and institutions worldwide. More information on speakers\, their affiliations\, and titles of their talks will be added as available. The Colloquium will zoom at 4:00PM  Tuesdays during the school year. Contact: Linda Earle lkn@mit.edu
URL:https://scienceinboston.com/event/biology-colloquium-series-3/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20210303T120000
DTEND;TZID=America/Vancouver:20210303T130000
DTSTAMP:20260404T010918
CREATED:20210301T180559Z
LAST-MODIFIED:20210301T180559Z
UID:13134-1614772800-1614776400@scienceinboston.com
SUMMARY:Information Session: CMeRIT Award
DESCRIPTION:Attend an information session to learn more about our KL2/CMeRIT program\, which offers advanced training through educational activities and mentored research for senior fellows and junior faculty in clinical and translational research. \nAn information session will be held via Zoom March 1 from 5:00-6:00pm. Additionally information can be found on our website.
URL:https://scienceinboston.com/event/information-session-cmerit-award/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20210303T120000
DTEND;TZID=America/Vancouver:20210303T130000
DTSTAMP:20260404T010918
CREATED:20210301T180559Z
LAST-MODIFIED:20210301T180559Z
UID:27662-1614772800-1614776400@scienceinboston.com
SUMMARY:Information Session: CMeRIT Award
DESCRIPTION:Attend an information session to learn more about our KL2/CMeRIT program\, which offers advanced training through educational activities and mentored research for senior fellows and junior faculty in clinical and translational research. \nAn information session will be held via Zoom March 1 from 5:00-6:00pm. Additionally information can be found on our website.
URL:https://scienceinboston.com/event/information-session-cmerit-award-2/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20210304T120000
DTEND;TZID=America/Vancouver:20210304T130000
DTSTAMP:20260404T010918
CREATED:20210301T181219Z
LAST-MODIFIED:20210301T181219Z
UID:13147-1614859200-1614862800@scienceinboston.com
SUMMARY:The Obesity Epidemic: The Lack Of Access To Care And Treatment
DESCRIPTION:Obesity is defined as a disease. Today obesity is one of the major cost drivers to our health care system\, linked to diabetes\, cardiovascular disease\, and cancer. There is ever-increasing medical evidence to support broader access to both evidence-based prevention programs in the community and active medical treatment of obesity. But proper care and treatment of obesity faces challenges in the form of perception\, stigma\, bias\, and roadblocks to accessing treatment\, therapies\, and care that can help patients. This forum\, sponsored by Novo Nordisk\, will address these issues and more.
URL:https://scienceinboston.com/event/the-obesity-epidemic-the-lack-of-access-to-care-and-treatment/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20210304T120000
DTEND;TZID=America/Vancouver:20210304T130000
DTSTAMP:20260404T010918
CREATED:20210301T181219Z
LAST-MODIFIED:20210301T181219Z
UID:27665-1614859200-1614862800@scienceinboston.com
SUMMARY:The Obesity Epidemic: The Lack Of Access To Care And Treatment
DESCRIPTION:Obesity is defined as a disease. Today obesity is one of the major cost drivers to our health care system\, linked to diabetes\, cardiovascular disease\, and cancer. There is ever-increasing medical evidence to support broader access to both evidence-based prevention programs in the community and active medical treatment of obesity. But proper care and treatment of obesity faces challenges in the form of perception\, stigma\, bias\, and roadblocks to accessing treatment\, therapies\, and care that can help patients. This forum\, sponsored by Novo Nordisk\, will address these issues and more.
URL:https://scienceinboston.com/event/the-obesity-epidemic-the-lack-of-access-to-care-and-treatment-2/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20210304T183000
DTEND;TZID=America/Vancouver:20210304T193000
DTSTAMP:20260404T010918
CREATED:20210301T180013Z
LAST-MODIFIED:20210301T180013Z
UID:13125-1614882600-1614886200@scienceinboston.com
SUMMARY:2021 Koch Institute Image Awards
DESCRIPTION:Join us for the virtual opening of the 2021 Image Awards exhibition. On the tenth anniversary of the dedication of MIT’s Koch Institute research facility\, peek inside our labs to glimpse new imagery that illuminates the scientific enterprise. Hear the stories behind this year’s award-winning visuals as we kick off our year-long celebration of the people\, projects\, and promise of integrative cancer research.
URL:https://scienceinboston.com/event/2021-koch-institute-image-awards/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20210304T183000
DTEND;TZID=America/Vancouver:20210304T193000
DTSTAMP:20260404T010918
CREATED:20210301T180013Z
LAST-MODIFIED:20210301T180013Z
UID:27659-1614882600-1614886200@scienceinboston.com
SUMMARY:2021 Koch Institute Image Awards
DESCRIPTION:Join us for the virtual opening of the 2021 Image Awards exhibition. On the tenth anniversary of the dedication of MIT’s Koch Institute research facility\, peek inside our labs to glimpse new imagery that illuminates the scientific enterprise. Hear the stories behind this year’s award-winning visuals as we kick off our year-long celebration of the people\, projects\, and promise of integrative cancer research.
URL:https://scienceinboston.com/event/2021-koch-institute-image-awards-2/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20210308T113000
DTEND;TZID=America/Vancouver:20210308T133000
DTSTAMP:20260404T010918
CREATED:20210301T181342Z
LAST-MODIFIED:20210301T181342Z
UID:13151-1615203000-1615210200@scienceinboston.com
SUMMARY:How We Lead – Perspectives From Two Key Biotechnology Hubs in North America
DESCRIPTION:Join us on International Women’s Day\, March 8\, 2021\, when WIB-Greater Montreal and WIB-Greater Boston will present a joint event with BIOQuébec and MassBio. \nBIOQuébec is committed to supporting Québec’s biotechnology and life sciences industry. MassBio’s mission is to advance Massachusetts’ leadership in the life sciences and each is dedicated to improving healthcare and quality of life. Join the discussion of the landscape in Quebec and Massachusetts and biotech leaders’ perspectives on challenges/obstacles faced\, leadership styles\, where do we want to be\, and how do we get there. \nThe event will be facilitated by journalist-columnist Tasha Kheiriddin with panelists from Québec: Anie Perrault\, executive director BIOQuébec\, Clarissa Desjardins\, founder and former CEO\, Clementia (now Ipsen)\, and Nadine Beauger\, President & CEO\, IRICOR and from Massachusetts: Kendalle Burin O’Connell\, President & COO MassBio\, Ramani Varanasi- President & CEO of X-Biotix Therapeutics\, and Liang Schweizer- CEO & CSO of HiFiBiO Therapeutics. \nPLEASE NOTE: You will be redirected to the Women In Bio event page by clicking\, “Register Now.” This event requires you to sign-in to receive a personalized link to the webinar. Please select “sign-in” and then choose “non-member.” The event is free for all MassBio members. \nDisclaimer: This event may be recorded. There is a possibility your image and/or voice may be a part of that recording. If you are uncomfortable\, please be sure to turn off your webcam.
URL:https://scienceinboston.com/event/how-we-lead-perspectives-from-two-key-biotechnology-hubs-in-north-america/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20210308T113000
DTEND;TZID=America/Vancouver:20210308T133000
DTSTAMP:20260404T010918
CREATED:20210301T181342Z
LAST-MODIFIED:20210301T181342Z
UID:27666-1615203000-1615210200@scienceinboston.com
SUMMARY:How We Lead – Perspectives From Two Key Biotechnology Hubs in North America
DESCRIPTION:Join us on International Women’s Day\, March 8\, 2021\, when WIB-Greater Montreal and WIB-Greater Boston will present a joint event with BIOQuébec and MassBio. \nBIOQuébec is committed to supporting Québec’s biotechnology and life sciences industry. MassBio’s mission is to advance Massachusetts’ leadership in the life sciences and each is dedicated to improving healthcare and quality of life. Join the discussion of the landscape in Quebec and Massachusetts and biotech leaders’ perspectives on challenges/obstacles faced\, leadership styles\, where do we want to be\, and how do we get there. \nThe event will be facilitated by journalist-columnist Tasha Kheiriddin with panelists from Québec: Anie Perrault\, executive director BIOQuébec\, Clarissa Desjardins\, founder and former CEO\, Clementia (now Ipsen)\, and Nadine Beauger\, President & CEO\, IRICOR and from Massachusetts: Kendalle Burin O’Connell\, President & COO MassBio\, Ramani Varanasi- President & CEO of X-Biotix Therapeutics\, and Liang Schweizer- CEO & CSO of HiFiBiO Therapeutics. \nPLEASE NOTE: You will be redirected to the Women In Bio event page by clicking\, “Register Now.” This event requires you to sign-in to receive a personalized link to the webinar. Please select “sign-in” and then choose “non-member.” The event is free for all MassBio members. \nDisclaimer: This event may be recorded. There is a possibility your image and/or voice may be a part of that recording. If you are uncomfortable\, please be sure to turn off your webcam.
URL:https://scienceinboston.com/event/how-we-lead-perspectives-from-two-key-biotechnology-hubs-in-north-america-2/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20210309
DTEND;VALUE=DATE:20210312
DTSTAMP:20260404T010918
CREATED:20210301T181748Z
LAST-MODIFIED:20210301T181748Z
UID:13157-1615248000-1615507199@scienceinboston.com
SUMMARY:Viral Vectors for Gene Therapy – Manufacturing
DESCRIPTION:Course Description\n\nThis course teaches fundamental concepts in viral vectors for gene therapy and how to manufacture them. The course utilizes case studies and laboratory practices to demonstrate critical steps in the production of viral vectors.\n\nInstructors \n\nDavid McNally (MassBiologics)\nPhillip Tai (UMass Medical School)\nShekar Ganesa (MassBiologics)\nSangmook Lee (MassBiologics)\nTom Larkin (MassBiologics)\nMike Pietila (MassBiologics)\nGretchen Gee (MassBiologics)\nMatthew Burak (MassBiologics)\n\nTarget Audience \n\nScientist\, Senior Research Scientist\, Bioprocess Engineer\, or equivalent in Pharmaceuticals\, Biopharmaceuticals\n\nObjective \n\nUnderstand the major viral vector systems used for gene therapy and their advantages and disadvantages\nUnderstand the major expression systems used to manufacture viral vectors for use in gene therapy\nUnderstand the biochemistry of viral vectors\, their quality attributes and how to measure them\nDescribe some common pitfalls to avoid when processing viral vectors\nExecute transient transfection processes for the production of AAV using suspension HEK293 cells and process the material generated using filtration and chromatographic methods\n\nModules \n\nM1. Intro to Viral Vectors and their use in gene therapy\nM2. Upstream processing of Viral Vectors\nM3. Tour of labs and cGMP facility\nM4. Introduction/safety – hands on lab based work\nM5. Hands on lab work – upstream methods\nM6. Downstream processing of Viral Vectors – Chromatography\nM7. Downstream processing of Viral Vectors – Filtration\nM8. Regulatory Considerations for Gene Therapy Products\nM9. Hands on lab work – Downstream Methods\nM10. Analytical Methods\nM11. Analytical Case Studies\nM12. Hands-on lab work – Analytical Methods\nM13. Review of Analytical Data
URL:https://scienceinboston.com/event/viral-vectors-for-gene-therapy-manufacturing/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20210309
DTEND;VALUE=DATE:20210312
DTSTAMP:20260404T010918
CREATED:20210301T181748Z
LAST-MODIFIED:20210301T181748Z
UID:27668-1615248000-1615507199@scienceinboston.com
SUMMARY:Viral Vectors for Gene Therapy – Manufacturing
DESCRIPTION:Course Description\n\nThis course teaches fundamental concepts in viral vectors for gene therapy and how to manufacture them. The course utilizes case studies and laboratory practices to demonstrate critical steps in the production of viral vectors.\n\nInstructors \n\nDavid McNally (MassBiologics)\nPhillip Tai (UMass Medical School)\nShekar Ganesa (MassBiologics)\nSangmook Lee (MassBiologics)\nTom Larkin (MassBiologics)\nMike Pietila (MassBiologics)\nGretchen Gee (MassBiologics)\nMatthew Burak (MassBiologics)\n\nTarget Audience \n\nScientist\, Senior Research Scientist\, Bioprocess Engineer\, or equivalent in Pharmaceuticals\, Biopharmaceuticals\n\nObjective \n\nUnderstand the major viral vector systems used for gene therapy and their advantages and disadvantages\nUnderstand the major expression systems used to manufacture viral vectors for use in gene therapy\nUnderstand the biochemistry of viral vectors\, their quality attributes and how to measure them\nDescribe some common pitfalls to avoid when processing viral vectors\nExecute transient transfection processes for the production of AAV using suspension HEK293 cells and process the material generated using filtration and chromatographic methods\n\nModules \n\nM1. Intro to Viral Vectors and their use in gene therapy\nM2. Upstream processing of Viral Vectors\nM3. Tour of labs and cGMP facility\nM4. Introduction/safety – hands on lab based work\nM5. Hands on lab work – upstream methods\nM6. Downstream processing of Viral Vectors – Chromatography\nM7. Downstream processing of Viral Vectors – Filtration\nM8. Regulatory Considerations for Gene Therapy Products\nM9. Hands on lab work – Downstream Methods\nM10. Analytical Methods\nM11. Analytical Case Studies\nM12. Hands-on lab work – Analytical Methods\nM13. Review of Analytical Data
URL:https://scienceinboston.com/event/viral-vectors-for-gene-therapy-manufacturing-2/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20210309T110000
DTEND;TZID=America/Vancouver:20210309T113000
DTSTAMP:20260404T010918
CREATED:20210301T181514Z
LAST-MODIFIED:20210301T181514Z
UID:13154-1615287600-1615289400@scienceinboston.com
SUMMARY:Massbio Town Hall: One Year on: How Has the Life Sciences Industry Changed to Address Current and Future Global Health Crises?
DESCRIPTION:The healthcare sector has undergone a rapid transformation in the year since COVID-19 cases began surging in the United States. From the evolution of drug and vaccine development to the increased correlation between public health outcomes and the global supply chain\, the life sciences have had to rapidly innovate and continuously iterate to address COVID-19’s wide ranging impact. With COVID-19 not disappearing in the short-term despite effective vaccines\, what are biotech and med tech companies doing to develop new solutions that will keep people healthy and out of the hospital in the near term while preparing us for the next global health crisis? \nOur March Town Hall\, in partnership with MassMEDIC\, will look at how the biopharma and medical technology industries responded to the COVID-19 pandemic and how they’re using what they learned over the past year to address and plan for current and future threats. \nWebinar link will be emailed to participants the day before – you can also access it from the “Live Stream” tab below. This event is for members-only. \nNOTE: MassBio makes every effort to accommodate our entire community at each of our events. Please let us know at least 3 days in advance of the event if you require special accommodations\, such as captioning.
URL:https://scienceinboston.com/event/massbio-town-hall-one-year-on-how-has-the-life-sciences-industry-changed-to-address-current-and-future-global-health-crises/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20210309T110000
DTEND;TZID=America/Vancouver:20210309T113000
DTSTAMP:20260404T010918
CREATED:20210301T181514Z
LAST-MODIFIED:20210301T181514Z
UID:27667-1615287600-1615289400@scienceinboston.com
SUMMARY:Massbio Town Hall: One Year on: How Has the Life Sciences Industry Changed to Address Current and Future Global Health Crises?
DESCRIPTION:The healthcare sector has undergone a rapid transformation in the year since COVID-19 cases began surging in the United States. From the evolution of drug and vaccine development to the increased correlation between public health outcomes and the global supply chain\, the life sciences have had to rapidly innovate and continuously iterate to address COVID-19’s wide ranging impact. With COVID-19 not disappearing in the short-term despite effective vaccines\, what are biotech and med tech companies doing to develop new solutions that will keep people healthy and out of the hospital in the near term while preparing us for the next global health crisis? \nOur March Town Hall\, in partnership with MassMEDIC\, will look at how the biopharma and medical technology industries responded to the COVID-19 pandemic and how they’re using what they learned over the past year to address and plan for current and future threats. \nWebinar link will be emailed to participants the day before – you can also access it from the “Live Stream” tab below. This event is for members-only. \nNOTE: MassBio makes every effort to accommodate our entire community at each of our events. Please let us know at least 3 days in advance of the event if you require special accommodations\, such as captioning.
URL:https://scienceinboston.com/event/massbio-town-hall-one-year-on-how-has-the-life-sciences-industry-changed-to-address-current-and-future-global-health-crises-2/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20210311T153000
DTEND;TZID=America/Vancouver:20210311T170000
DTSTAMP:20260404T010918
CREATED:20210301T181958Z
LAST-MODIFIED:20210301T181958Z
UID:13166-1615476600-1615482000@scienceinboston.com
SUMMARY:MassBio’s Virtual St. Patrick’s Day Mixer
DESCRIPTION:Get your networking on and raise a pint to this year’s Virtual St. Paddy’s Day Mixer! Get in the festive spirit and wear your green. A prize will be given to the best dressed. Thank you to G&L Scientific for donating a $100 Uber Eats gift card to the winner. We will use Zoom and divide into smaller groups to give everyone the chance to speak and hear from each other. We will have three rounds of networking with a new group of people in each round. We encourage you to come prepared to give a brief intro to your group and we will help by giving prompt questions throughout the event. \nFree for MassBio Members. Registration is required. \nTo inquire about sponsorship opportunities\, contact Lea Cherchia or Jessica Sousa \nDetails for accessing the meeting will be emailed to you the day prior. Users that join the Zoom meeting from the Zoom Mobile App can participate in breakout rooms. Users that join using Chromebooks/Chrome OS or Zoom Rooms are unable to join breakout rooms. \nMassBio makes every effort to accommodate our entire community at each of our events. Please let us know at least 3 days in advance of the event if you require special accommodations\, such as captioning.
URL:https://scienceinboston.com/event/massbios-virtual-st-patricks-day-mixer/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20210311T153000
DTEND;TZID=America/Vancouver:20210311T170000
DTSTAMP:20260404T010918
CREATED:20210301T181958Z
LAST-MODIFIED:20210301T181958Z
UID:27670-1615476600-1615482000@scienceinboston.com
SUMMARY:MassBio’s Virtual St. Patrick’s Day Mixer
DESCRIPTION:Get your networking on and raise a pint to this year’s Virtual St. Paddy’s Day Mixer! Get in the festive spirit and wear your green. A prize will be given to the best dressed. Thank you to G&L Scientific for donating a $100 Uber Eats gift card to the winner. We will use Zoom and divide into smaller groups to give everyone the chance to speak and hear from each other. We will have three rounds of networking with a new group of people in each round. We encourage you to come prepared to give a brief intro to your group and we will help by giving prompt questions throughout the event. \nFree for MassBio Members. Registration is required. \nTo inquire about sponsorship opportunities\, contact Lea Cherchia or Jessica Sousa \nDetails for accessing the meeting will be emailed to you the day prior. Users that join the Zoom meeting from the Zoom Mobile App can participate in breakout rooms. Users that join using Chromebooks/Chrome OS or Zoom Rooms are unable to join breakout rooms. \nMassBio makes every effort to accommodate our entire community at each of our events. Please let us know at least 3 days in advance of the event if you require special accommodations\, such as captioning.
URL:https://scienceinboston.com/event/massbios-virtual-st-patricks-day-mixer-2/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20210315T120000
DTEND;TZID=America/Vancouver:20210315T130000
DTSTAMP:20260404T010918
CREATED:20201217T211944Z
LAST-MODIFIED:20201217T211944Z
UID:12208-1615809600-1615813200@scienceinboston.com
SUMMARY:Research Connection Live: Virtual Edition
DESCRIPTION:RC LIVE focus on announcements\, resources and information relevant to the research community. There is a very robust list of standing attendees who come each month to be available to the research community to help them answer questions and navigate obstacles. RC LIVE are open to all and an excellent resource – these are intended to be the forum for PIs to find the answers to many of their questions. Come each month to hear the latest news from community leaders and ask your questions.
URL:https://scienceinboston.com/event/research-connection-live-virtual-edition-4/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20210315T120000
DTEND;TZID=America/Vancouver:20210315T130000
DTSTAMP:20260404T010918
CREATED:20201217T211944Z
LAST-MODIFIED:20201217T211944Z
UID:27629-1615809600-1615813200@scienceinboston.com
SUMMARY:Research Connection Live: Virtual Edition
DESCRIPTION:RC LIVE focus on announcements\, resources and information relevant to the research community. There is a very robust list of standing attendees who come each month to be available to the research community to help them answer questions and navigate obstacles. RC LIVE are open to all and an excellent resource – these are intended to be the forum for PIs to find the answers to many of their questions. Come each month to hear the latest news from community leaders and ask your questions.
URL:https://scienceinboston.com/event/research-connection-live-virtual-edition-4-2/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20210316T130000
DTEND;TZID=America/Vancouver:20210316T140000
DTSTAMP:20260404T010918
CREATED:20210301T180931Z
LAST-MODIFIED:20210301T180931Z
UID:13137-1615899600-1615903200@scienceinboston.com
SUMMARY:Interdisciplinary Neuroscience Colloquia of Extramural Postdoctoral Talks
DESCRIPTION:INCEPT —Interdisciplinary Neuroscience Colloquia of Extramural Postdoctoral Talks\, is a new talk series organized by the INCEPT committee of Neurobio Postdoc Club to provide exceptional senior postdocs with more opportunities to receive feedback and practice their prospective job talks. \nSpeaker: Dr. DelSignore\nTopic: Organization and regulation of synaptic endocytic machinery \nThe synaptic endocytic machinery regulates the traffic of cargoes important for synaptic development\, activity\, and plasticity\, and defects in this machinery are associated with a variety of neurological diseases. Unlike non-neuronal cells\, in which endocytic machinery assembles transiently at discrete 50-100nm sites of endocytosis\, the synaptic endocytic machinery assembles persistently at membranes in a poorly understood micron scale domain called the ‘Periactive Zone (PAZ)’\, within which active endocytic events occur sparsely in space and time. This suggests that there are neuron-specific mechanisms to broadly organize and then locally activate this machinery. Problem: How does micron-scale PAZ machinery direct nano-scale endocytic events? \nWe previously found that the PAZ protein Nervous Wreck couples membrane remodeling to force-generating actin assembly\, but is locked in an autoinhibited state even after it associates with membranes. I hypothesized that local relief of autoregulation could promote discrete membrane remodeling events. Using in vitro assays\, I found that SH3-mediated interactions among Nervous Wreck\, the actin assembly factor WASp\, and the scaffold Dap160/Intersectin cooperate to fully relieve autoinhibition of membrane binding and actin assembly. To test how this mechanism regulates synaptic endocytosis\, I developed novel methods at the Drosophila neuromuscular junction to quantify PAZ activation by quantitative live imaging of actin assembly\, and PAZ organization by super-resolution microscopy. I found that loss of Nervous Wreck\, Dap160\, or their interaction resulted in short-lived\, likely unproductive actin assembly\, and compromised synaptic endocytosis. In currently ongoing work\, I am further investigating the mechanisms that organize PAZ micron-scale architecture. I find that the same SH3 interactions that promote PAZ activation are also required for its micron-scale architecture at synapses\, and drive phase separation in vitro\, suggesting a biochemical mechanism for micron-scale assembly. This raises the exciting question of how phase separation and autoregulation might collaboratively organize PAZ architecture and function.\nSocial for postdocs and students to follow. \nPlease email neurobiopostoc@gmail.com for all zoom links
URL:https://scienceinboston.com/event/interdisciplinary-neuroscience-colloquia-of-extramural-postdoctoral-talks/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20210316T130000
DTEND;TZID=America/Vancouver:20210316T140000
DTSTAMP:20260404T010918
CREATED:20210301T180931Z
LAST-MODIFIED:20210301T180931Z
UID:27663-1615899600-1615903200@scienceinboston.com
SUMMARY:Interdisciplinary Neuroscience Colloquia of Extramural Postdoctoral Talks
DESCRIPTION:INCEPT —Interdisciplinary Neuroscience Colloquia of Extramural Postdoctoral Talks\, is a new talk series organized by the INCEPT committee of Neurobio Postdoc Club to provide exceptional senior postdocs with more opportunities to receive feedback and practice their prospective job talks. \nSpeaker: Dr. DelSignore\nTopic: Organization and regulation of synaptic endocytic machinery \nThe synaptic endocytic machinery regulates the traffic of cargoes important for synaptic development\, activity\, and plasticity\, and defects in this machinery are associated with a variety of neurological diseases. Unlike non-neuronal cells\, in which endocytic machinery assembles transiently at discrete 50-100nm sites of endocytosis\, the synaptic endocytic machinery assembles persistently at membranes in a poorly understood micron scale domain called the ‘Periactive Zone (PAZ)’\, within which active endocytic events occur sparsely in space and time. This suggests that there are neuron-specific mechanisms to broadly organize and then locally activate this machinery. Problem: How does micron-scale PAZ machinery direct nano-scale endocytic events? \nWe previously found that the PAZ protein Nervous Wreck couples membrane remodeling to force-generating actin assembly\, but is locked in an autoinhibited state even after it associates with membranes. I hypothesized that local relief of autoregulation could promote discrete membrane remodeling events. Using in vitro assays\, I found that SH3-mediated interactions among Nervous Wreck\, the actin assembly factor WASp\, and the scaffold Dap160/Intersectin cooperate to fully relieve autoinhibition of membrane binding and actin assembly. To test how this mechanism regulates synaptic endocytosis\, I developed novel methods at the Drosophila neuromuscular junction to quantify PAZ activation by quantitative live imaging of actin assembly\, and PAZ organization by super-resolution microscopy. I found that loss of Nervous Wreck\, Dap160\, or their interaction resulted in short-lived\, likely unproductive actin assembly\, and compromised synaptic endocytosis. In currently ongoing work\, I am further investigating the mechanisms that organize PAZ micron-scale architecture. I find that the same SH3 interactions that promote PAZ activation are also required for its micron-scale architecture at synapses\, and drive phase separation in vitro\, suggesting a biochemical mechanism for micron-scale assembly. This raises the exciting question of how phase separation and autoregulation might collaboratively organize PAZ architecture and function.\nSocial for postdocs and students to follow. \nPlease email neurobiopostoc@gmail.com for all zoom links
URL:https://scienceinboston.com/event/interdisciplinary-neuroscience-colloquia-of-extramural-postdoctoral-talks-2/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20210317T130000
DTEND;TZID=America/Vancouver:20210317T140000
DTSTAMP:20260404T010918
CREATED:20210301T181913Z
LAST-MODIFIED:20210301T181913Z
UID:13162-1615986000-1615989600@scienceinboston.com
SUMMARY:Find New Leads from Peptides and Natural Ligands
DESCRIPTION:Virtual screening can be a very efficient way to identify initial lead molecules or a back-up series for a drug discovery program. Obvious advantages include access to increased molecular diversity\, an ability to find new IP\, savings in time and ultimately cost. One of the most critical challenges of virtual screening is determining the most effective screening strategy: this implies working through the data and detail of the experimental design to achieve the desired outcome for any given starting point. \nIn this webinar we will show how Flare™\, Forge™ and Blaze™ can be used to analyze and develop an appropriate virtual screening strategy for complex target systems for which no simple small ligands exists\, and how that can be worked into an effective virtual screen.
URL:https://scienceinboston.com/event/find-new-leads-from-peptides-and-natural-ligands/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20210317T130000
DTEND;TZID=America/Vancouver:20210317T140000
DTSTAMP:20260404T010918
CREATED:20210301T181913Z
LAST-MODIFIED:20210301T181913Z
UID:27669-1615986000-1615989600@scienceinboston.com
SUMMARY:Find New Leads from Peptides and Natural Ligands
DESCRIPTION:Virtual screening can be a very efficient way to identify initial lead molecules or a back-up series for a drug discovery program. Obvious advantages include access to increased molecular diversity\, an ability to find new IP\, savings in time and ultimately cost. One of the most critical challenges of virtual screening is determining the most effective screening strategy: this implies working through the data and detail of the experimental design to achieve the desired outcome for any given starting point. \nIn this webinar we will show how Flare™\, Forge™ and Blaze™ can be used to analyze and develop an appropriate virtual screening strategy for complex target systems for which no simple small ligands exists\, and how that can be worked into an effective virtual screen.
URL:https://scienceinboston.com/event/find-new-leads-from-peptides-and-natural-ligands-2/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20210318T110000
DTEND;TZID=America/Vancouver:20210318T120000
DTSTAMP:20260404T010918
CREATED:20210315T154828Z
LAST-MODIFIED:20210315T154828Z
UID:13365-1616065200-1616068800@scienceinboston.com
SUMMARY:MassBio Virtual Speed Networking
DESCRIPTION:Join MassBio for a Virtual Speed Networking Mixer! If you want to grow your network\, meet others individually and do not have the time for a long event\, then this virtual mixer is perfect for you. There will be short rounds of one-on-one networking with a different person assigned each rotation. Leave the event with new connections all under 1 hour! \nAttendeess will be entered into a raffle to win a $50 gift card to Gather in the Seaport District. \nFree for MassBio Members. Registration is required. \nTo inquire about sponsorship opportunities\, contact Lea Cherchia or Jessica Sousa. \nMassBio makes every effort to accommodate our entire community at each of our events. Please let us know at least 3 days in advance of the event if you require special accommodations\, such as captioning.
URL:https://scienceinboston.com/event/massbio-virtual-speed-networking/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20210318T110000
DTEND;TZID=America/Vancouver:20210318T120000
DTSTAMP:20260404T010918
CREATED:20210315T154828Z
LAST-MODIFIED:20210315T154828Z
UID:27672-1616065200-1616068800@scienceinboston.com
SUMMARY:MassBio Virtual Speed Networking
DESCRIPTION:Join MassBio for a Virtual Speed Networking Mixer! If you want to grow your network\, meet others individually and do not have the time for a long event\, then this virtual mixer is perfect for you. There will be short rounds of one-on-one networking with a different person assigned each rotation. Leave the event with new connections all under 1 hour! \nAttendeess will be entered into a raffle to win a $50 gift card to Gather in the Seaport District. \nFree for MassBio Members. Registration is required. \nTo inquire about sponsorship opportunities\, contact Lea Cherchia or Jessica Sousa. \nMassBio makes every effort to accommodate our entire community at each of our events. Please let us know at least 3 days in advance of the event if you require special accommodations\, such as captioning.
URL:https://scienceinboston.com/event/massbio-virtual-speed-networking-2/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20210319T190000
DTEND;TZID=America/New_York:20210319T200000
DTSTAMP:20260404T010918
CREATED:20210319T180857Z
LAST-MODIFIED:20210319T180857Z
UID:13454-1616180400-1616184000@scienceinboston.com
SUMMARY:Pioneering Medicines and Health Security with Noubar Afeyan
DESCRIPTION:You are invited to join Ruth Lehmann\, President and Director of Whitehead Institute\, for a series of virtual dialogues with scientific luminaries from academia\, and visionary leaders from the biotech industry. \nWhat trends in science and technology excite them the most? Which innovations have the potential to dramatically impact the way we live and work? \nBe a part of the conversation.
URL:https://scienceinboston.com/event/pioneering-medicines-and-health-security-with-noubar-afeyan/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20210319T190000
DTEND;TZID=America/New_York:20210319T200000
DTSTAMP:20260404T010918
CREATED:20210319T180857Z
LAST-MODIFIED:20210319T180857Z
UID:27675-1616180400-1616184000@scienceinboston.com
SUMMARY:Pioneering Medicines and Health Security with Noubar Afeyan
DESCRIPTION:You are invited to join Ruth Lehmann\, President and Director of Whitehead Institute\, for a series of virtual dialogues with scientific luminaries from academia\, and visionary leaders from the biotech industry. \nWhat trends in science and technology excite them the most? Which innovations have the potential to dramatically impact the way we live and work? \nBe a part of the conversation.
URL:https://scienceinboston.com/event/pioneering-medicines-and-health-security-with-noubar-afeyan-2/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20210322T160000
DTEND;TZID=America/Vancouver:20210322T170000
DTSTAMP:20260404T010918
CREATED:20210301T180138Z
LAST-MODIFIED:20210301T180138Z
UID:13128-1616428800-1616432400@scienceinboston.com
SUMMARY:2021 Phillip A. Sharp Lecture in Neural Circuits
DESCRIPTION:Abstract: Both computational and experimental results in single neurons and small networks demonstrate that very similar network function can result from quite disparate sets of neuronal and network parameters.  Using the crustacean stomatogastric nervous system\, we now study the influence of these differences in underlying structure on differential resilience of individuals to a variety of environmental perturbations\, including changes in temperature\, pH\, potassium concentration and neuromodulation.  We show that neurons with many different kinds of ion channels can smoothly move through different mechanisms in generating their activity patterns\, thus extending their dynamic range. \nBiography: Eve Marder is currently the Victor and Gwendolyn Beinfield Professor of Neuroscience at Brandeis University. Her research gave key insights into rhythmic motor pattern generation\, neuromodulation\, homeostatic regulation of neurons and networks\, and the use of the dynamic clamp. Marder is a past president of the Society for Neuroscience\, and a member of the National Academy of Sciences\, the American Academy of Sciences\, and a fellow of the American Association for the Advancement of Science and the Biophysical Society. Marder is also a member of the Institute of Medicine’s Neuroscience Forum and a member of the National Advisory Neurological Disorders and Stroke (NANDS) Council. \nRegister in advance for this webinar:\nhttps://mit.zoom.us/webinar/register/WN_uNARVdP7Q_ORbx0MohGtPQ
URL:https://scienceinboston.com/event/2021-phillip-a-sharp-lecture-in-neural-circuits/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20210322T160000
DTEND;TZID=America/Vancouver:20210322T170000
DTSTAMP:20260404T010918
CREATED:20210301T180138Z
LAST-MODIFIED:20210301T180138Z
UID:27660-1616428800-1616432400@scienceinboston.com
SUMMARY:2021 Phillip A. Sharp Lecture in Neural Circuits
DESCRIPTION:Abstract: Both computational and experimental results in single neurons and small networks demonstrate that very similar network function can result from quite disparate sets of neuronal and network parameters.  Using the crustacean stomatogastric nervous system\, we now study the influence of these differences in underlying structure on differential resilience of individuals to a variety of environmental perturbations\, including changes in temperature\, pH\, potassium concentration and neuromodulation.  We show that neurons with many different kinds of ion channels can smoothly move through different mechanisms in generating their activity patterns\, thus extending their dynamic range. \nBiography: Eve Marder is currently the Victor and Gwendolyn Beinfield Professor of Neuroscience at Brandeis University. Her research gave key insights into rhythmic motor pattern generation\, neuromodulation\, homeostatic regulation of neurons and networks\, and the use of the dynamic clamp. Marder is a past president of the Society for Neuroscience\, and a member of the National Academy of Sciences\, the American Academy of Sciences\, and a fellow of the American Association for the Advancement of Science and the Biophysical Society. Marder is also a member of the Institute of Medicine’s Neuroscience Forum and a member of the National Advisory Neurological Disorders and Stroke (NANDS) Council. \nRegister in advance for this webinar:\nhttps://mit.zoom.us/webinar/register/WN_uNARVdP7Q_ORbx0MohGtPQ
URL:https://scienceinboston.com/event/2021-phillip-a-sharp-lecture-in-neural-circuits-2/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20210323T160000
DTEND;TZID=America/Vancouver:20210323T170000
DTSTAMP:20260404T010918
CREATED:20210301T180239Z
LAST-MODIFIED:20210301T180239Z
UID:13131-1616515200-1616518800@scienceinboston.com
SUMMARY:Biology Colloquium Series
DESCRIPTION:Speaker: Dr. Melanie Ott\, Gladstone Institute. \nHosted by: Laurie Boyer. \nTitle: “New approaches to testing and treating SARS-CoV-2” . \nThe Biology Colloquium is a weekly seminar held throughout the academic year\, featuring distinguished speakers in many areas of the biological sciences\, from universities and institutions worldwide. More information on speakers\, their affiliations\, and titles of their talks will be added as available. The Colloquium will zoom at 4:00PM  Tuesdays during the school year. Contact: Linda Earle lkn@mit.edu
URL:https://scienceinboston.com/event/biology-colloquium-series-2/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20210323T160000
DTEND;TZID=America/Vancouver:20210323T170000
DTSTAMP:20260404T010918
CREATED:20210301T180239Z
LAST-MODIFIED:20210301T180239Z
UID:27661-1616515200-1616518800@scienceinboston.com
SUMMARY:Biology Colloquium Series
DESCRIPTION:Speaker: Dr. Melanie Ott\, Gladstone Institute. \nHosted by: Laurie Boyer. \nTitle: “New approaches to testing and treating SARS-CoV-2” . \nThe Biology Colloquium is a weekly seminar held throughout the academic year\, featuring distinguished speakers in many areas of the biological sciences\, from universities and institutions worldwide. More information on speakers\, their affiliations\, and titles of their talks will be added as available. The Colloquium will zoom at 4:00PM  Tuesdays during the school year. Contact: Linda Earle lkn@mit.edu
URL:https://scienceinboston.com/event/biology-colloquium-series-2-2/
LOCATION:Online
END:VEVENT
END:VCALENDAR