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BEGIN:VEVENT
DTSTART;TZID=America/New_York:20210406T170000
DTEND;TZID=America/New_York:20210406T180000
DTSTAMP:20260621T031653
CREATED:20210324T231701Z
LAST-MODIFIED:20210324T231732Z
UID:13546-1617728400-1617732000@scienceinboston.com
SUMMARY:Science for All Seasons - Proteomics: Translating the Code of Life
DESCRIPTION:The genome encodes the basic blueprints and switches underlying everything a cell does\, but it’s the proteome — the cell’s collection of proteins — that does the work of carrying signals\, turning circuits on and off\, processing energy\, and more. How do researchers study the proteome\, and how does that knowledge translate into new approaches to treating disease? Research scientist Namrata Udeshi and physician-scientist Michael Gillette will take us on a tour of the proteome and some of the opportunities that the science of proteomics presents for advancing human health.
URL:https://scienceinboston.com/event/science-for-all-seasons-proteomics-translating-the-code-of-life/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20210406T170000
DTEND;TZID=America/New_York:20210406T180000
DTSTAMP:20260621T031653
CREATED:20210324T231701Z
LAST-MODIFIED:20210324T231701Z
UID:27680-1617728400-1617732000@scienceinboston.com
SUMMARY:Science for All Seasons - Proteomics: Translating the Code of Life
DESCRIPTION:The genome encodes the basic blueprints and switches underlying everything a cell does\, but it’s the proteome — the cell’s collection of proteins — that does the work of carrying signals\, turning circuits on and off\, processing energy\, and more. How do researchers study the proteome\, and how does that knowledge translate into new approaches to treating disease? Research scientist Namrata Udeshi and physician-scientist Michael Gillette will take us on a tour of the proteome and some of the opportunities that the science of proteomics presents for advancing human health.
URL:https://scienceinboston.com/event/science-for-all-seasons-proteomics-translating-the-code-of-life-2/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20210406T160000
DTEND;TZID=America/New_York:20210406T170000
DTSTAMP:20260621T031653
CREATED:20210325T165729Z
LAST-MODIFIED:20210325T165729Z
UID:13560-1617724800-1617728400@scienceinboston.com
SUMMARY:Biology Colloquium Series (Dr. Dianne Newman)
DESCRIPTION:Speaker: Dr. Dianne K. Newman\, California Institute of Technology\, hosted by the Chipperfield Graduate Committee. Title: “Context matters: the agathokakological roles of redox-active “antibiotics”. The Biology Colloquium is a weekly seminar held throughout the academic year\, featuring distinguished speakers in many areas of the biological sciences\, from universities and institutions worldwide. More information on speakers\, their affiliations\, and titles of their talks will be added as available. The Colloquium will zoom at 4:00PM  Tuesdays during the school year. Contact: Linda Earle lkn@mit.edu \n 
URL:https://scienceinboston.com/event/biology-colloquium-series-dr-dianne-newman/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20210406T160000
DTEND;TZID=America/New_York:20210406T170000
DTSTAMP:20260621T031653
CREATED:20210325T165729Z
LAST-MODIFIED:20210325T165729Z
UID:27683-1617724800-1617728400@scienceinboston.com
SUMMARY:Biology Colloquium Series (Dr. Dianne Newman)
DESCRIPTION:Speaker: Dr. Dianne K. Newman\, California Institute of Technology\, hosted by the Chipperfield Graduate Committee. Title: “Context matters: the agathokakological roles of redox-active “antibiotics”. The Biology Colloquium is a weekly seminar held throughout the academic year\, featuring distinguished speakers in many areas of the biological sciences\, from universities and institutions worldwide. More information on speakers\, their affiliations\, and titles of their talks will be added as available. The Colloquium will zoom at 4:00PM  Tuesdays during the school year. Contact: Linda Earle lkn@mit.edu \n 
URL:https://scienceinboston.com/event/biology-colloquium-series-dr-dianne-newman-2/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20210405T160000
DTEND;TZID=America/New_York:20210405T170000
DTSTAMP:20260621T031653
CREATED:20210325T165855Z
LAST-MODIFIED:20210325T165912Z
UID:13563-1617638400-1617642000@scienceinboston.com
SUMMARY:Joshua Sanes | Cell Types as Building Blocks of Neural Circuits
DESCRIPTION:Join us for the 2021 Edward M. Scolnick Prize in Neuroscience Lecture \nCell Types as Building Blocks of Neural Circuits \nJoshua Sanes\, Harvard University \nAbstract: Classification of neurons was a major preoccupation of Cajal\, but later came to be viewed as a fairly boring enterprise. Over the past few decades\, however\, inability to define neuronal types emerged as a major bottleneck in analysis of neural circuits and brain disorders. The introduction of high throughput single cell RNAseq in 2015 provided a new way to approach this problem. I will describe its use to generate an atlas of 130 cell types from mouse retina\, a particularly accessible part of the brain\, and then show how the atlas can be used to probe development\, function and dysfunction in new ways: (1) Profiling embryonic retinal ganglion cells (RGCs) to learn how they diversify into ~45 types. (2) Analyzing RGC types following damage to demonstrate dramatic differences in their resilience to injury and identify genes that contribute to resilience. (3) Generating primate retinal atlases and using them to assess expression of genes implicated in blinding diseases. (4) Probing the evolution of cell types by profiling cells from many vertebrate species. \nRegister in advance for this webinar: https://mit.zoom.us/webinar/register/WN_pwTd05G6RlWhwXgMMFhv1w
URL:https://scienceinboston.com/event/joshua-sanes-cell-types-as-building-blocks-of-neural-circuits/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20210405T160000
DTEND;TZID=America/New_York:20210405T170000
DTSTAMP:20260621T031653
CREATED:20210325T165855Z
LAST-MODIFIED:20210325T165855Z
UID:27684-1617638400-1617642000@scienceinboston.com
SUMMARY:Joshua Sanes | Cell Types as Building Blocks of Neural Circuits
DESCRIPTION:Join us for the 2021 Edward M. Scolnick Prize in Neuroscience Lecture \nCell Types as Building Blocks of Neural Circuits \nJoshua Sanes\, Harvard University \nAbstract: Classification of neurons was a major preoccupation of Cajal\, but later came to be viewed as a fairly boring enterprise. Over the past few decades\, however\, inability to define neuronal types emerged as a major bottleneck in analysis of neural circuits and brain disorders. The introduction of high throughput single cell RNAseq in 2015 provided a new way to approach this problem. I will describe its use to generate an atlas of 130 cell types from mouse retina\, a particularly accessible part of the brain\, and then show how the atlas can be used to probe development\, function and dysfunction in new ways: (1) Profiling embryonic retinal ganglion cells (RGCs) to learn how they diversify into ~45 types. (2) Analyzing RGC types following damage to demonstrate dramatic differences in their resilience to injury and identify genes that contribute to resilience. (3) Generating primate retinal atlases and using them to assess expression of genes implicated in blinding diseases. (4) Probing the evolution of cell types by profiling cells from many vertebrate species. \nRegister in advance for this webinar: https://mit.zoom.us/webinar/register/WN_pwTd05G6RlWhwXgMMFhv1w
URL:https://scienceinboston.com/event/joshua-sanes-cell-types-as-building-blocks-of-neural-circuits-2/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20210405T140000
DTEND;TZID=America/Vancouver:20210405T150000
DTSTAMP:20260621T031653
CREATED:20210315T154739Z
LAST-MODIFIED:20210315T154935Z
UID:13361-1617631200-1617634800@scienceinboston.com
SUMMARY:Ensuring Equitable Access To New Gene Therapies
DESCRIPTION:While recent clinical trials of innovative\, new gene therapies show incredible promise for patients who have faced a lifetime of unmet medical needs\, the biggest challenge for these therapies is yet to come – ensuring equitable access. \nA critical moment for this issue could be the development of new therapies for sickle cell disease\, which affects approximately one in 365 Black Americans. What can the life sciences do to ensure that all patients have access to what could be life-changing medicines? \nIn this month’s Make Shift Happen\, panelists from the gene therapy sector and patient advocacy space will discuss: \n\nThe current state of ED&I in therapeutic development\nTaking a patient-centric approach to developing new gene therapies\nChallenges and opportunities for improving therapeutic accessibility
URL:https://scienceinboston.com/event/ensuring-equitable-access-to-new-gene-therapies/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20210405T140000
DTEND;TZID=America/Vancouver:20210405T150000
DTSTAMP:20260621T031653
CREATED:20210315T154739Z
LAST-MODIFIED:20210315T154739Z
UID:27671-1617631200-1617634800@scienceinboston.com
SUMMARY:Ensuring Equitable Access To New Gene Therapies
DESCRIPTION:While recent clinical trials of innovative\, new gene therapies show incredible promise for patients who have faced a lifetime of unmet medical needs\, the biggest challenge for these therapies is yet to come – ensuring equitable access. \nA critical moment for this issue could be the development of new therapies for sickle cell disease\, which affects approximately one in 365 Black Americans. What can the life sciences do to ensure that all patients have access to what could be life-changing medicines? \nIn this month’s Make Shift Happen\, panelists from the gene therapy sector and patient advocacy space will discuss: \n\nThe current state of ED&I in therapeutic development\nTaking a patient-centric approach to developing new gene therapies\nChallenges and opportunities for improving therapeutic accessibility
URL:https://scienceinboston.com/event/ensuring-equitable-access-to-new-gene-therapies-2/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20210401T120000
DTEND;TZID=America/New_York:20210401T130000
DTSTAMP:20260621T031653
CREATED:20210322T203008Z
LAST-MODIFIED:20210322T203030Z
UID:13486-1617278400-1617282000@scienceinboston.com
SUMMARY:Open Box Science Thursday Webinar Series: Targeting Microglia and Macrophages in Aging and Neurodegeneration
DESCRIPTION:SPEAKERS:\nParas Minhas | Stanford University\nRestoring metabolism of myeloid cells reverses cognitive decline in ageing (Nature 2021) \nAude Chiot | Oregon Health & Science University\nModifying macrophages at the periphery has the capacity to change microglial reactivity and to extend ALS survival (Nat Neurosci 2021) \nMODERATOR:\nLindsay Welikovitch | Massachusetts General Hospital
URL:https://scienceinboston.com/event/open-box-science-thursday-webinar-series-targeting-microglia-and-macrophages-in-aging-and-neurodegeneration/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20210401T120000
DTEND;TZID=America/New_York:20210401T130000
DTSTAMP:20260621T031653
CREATED:20210322T203008Z
LAST-MODIFIED:20210322T203008Z
UID:27679-1617278400-1617282000@scienceinboston.com
SUMMARY:Open Box Science Thursday Webinar Series: Targeting Microglia and Macrophages in Aging and Neurodegeneration
DESCRIPTION:SPEAKERS:\nParas Minhas | Stanford University\nRestoring metabolism of myeloid cells reverses cognitive decline in ageing (Nature 2021) \nAude Chiot | Oregon Health & Science University\nModifying macrophages at the periphery has the capacity to change microglial reactivity and to extend ALS survival (Nat Neurosci 2021) \nMODERATOR:\nLindsay Welikovitch | Massachusetts General Hospital
URL:https://scienceinboston.com/event/open-box-science-thursday-webinar-series-targeting-microglia-and-macrophages-in-aging-and-neurodegeneration-2/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20210330T160000
DTEND;TZID=America/New_York:20210330T170000
DTSTAMP:20260621T031653
CREATED:20210326T232438Z
LAST-MODIFIED:20210326T232438Z
UID:13607-1617120000-1617123600@scienceinboston.com
SUMMARY:Biology Colloquium Series (Dr. Cassandra Extavour)
DESCRIPTION:Speaker: Dr. Cassandra Extavour\, Harvard University. Hosted by Ruth Lehmann. Title: “Take your place! A new mechanism driving nuclear movement during embryogenesis.” The Biology Colloquium is a weekly seminar held throughout the academic year\, featuring distinguished speakers in many areas of the biological sciences\, from universities and institutions worldwide. More information on speakers\, their affiliations\, and titles of their talks will be added as available. The Colloquium will zoom at 4:00PM  Tuesdays during the school year. Contact: Linda Earle lkn@mit.edu
URL:https://scienceinboston.com/event/biology-colloquium-series-dr-cassandra-extavour/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20210330T160000
DTEND;TZID=America/New_York:20210330T170000
DTSTAMP:20260621T031653
CREATED:20210326T232438Z
LAST-MODIFIED:20210326T232438Z
UID:27685-1617120000-1617123600@scienceinboston.com
SUMMARY:Biology Colloquium Series (Dr. Cassandra Extavour)
DESCRIPTION:Speaker: Dr. Cassandra Extavour\, Harvard University. Hosted by Ruth Lehmann. Title: “Take your place! A new mechanism driving nuclear movement during embryogenesis.” The Biology Colloquium is a weekly seminar held throughout the academic year\, featuring distinguished speakers in many areas of the biological sciences\, from universities and institutions worldwide. More information on speakers\, their affiliations\, and titles of their talks will be added as available. The Colloquium will zoom at 4:00PM  Tuesdays during the school year. Contact: Linda Earle lkn@mit.edu
URL:https://scienceinboston.com/event/biology-colloquium-series-dr-cassandra-extavour-2/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20210329T170000
DTEND;TZID=America/New_York:20210329T183000
DTSTAMP:20260621T031653
CREATED:20210322T185134Z
LAST-MODIFIED:20210322T185134Z
UID:13475-1617037200-1617042600@scienceinboston.com
SUMMARY:MIT Research Slam Competition Public Showcase
DESCRIPTION:Interested in hearing about cool & cutting-edge research at MIT from excellent science communicators? Register to attend MIT’s first Research Slam Showcase\, a public showcase of research by MIT graduate students & scholars with prizes for the best communicators. The showcase will feature participants explaining their research and its importance in 3 minutes or less\, with judging by an expert panel of judges and by YOU\, the audience. \nThe 90-minute program will include live viewing of finalist Slam submissions\, evaluation & feedback from judges\, and a declaration of winners. Attendees can join in the fun by asking questions to participants\, leaving comments\, and voting for the audience-choice awards. So\, come join us for a celebration of innovative research and clear communication at MIT! \nThe Slam Showcase is free and open to everybody and anybody\, so please share with your friends & family. You can find more information at researchslam.mit.edu\, and please don’t hesitate to contact us with any questions! \nRegister to attend at: https://mit.zoom.us/webinar/register/WN_hI6g1uIxQh6xAWchqpkV1w
URL:https://scienceinboston.com/event/mit-research-slam-competition-public-showcase/
LOCATION:Online
ATTACH;FMTTYPE=image/png:https://scienceinboston.com/wp-content/uploads/sites/6/2021/03/3MT-Research-Slam-Logo-Final.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20210329T170000
DTEND;TZID=America/New_York:20210329T183000
DTSTAMP:20260621T031653
CREATED:20210322T185134Z
LAST-MODIFIED:20210322T185134Z
UID:27676-1617037200-1617042600@scienceinboston.com
SUMMARY:MIT Research Slam Competition Public Showcase
DESCRIPTION:Interested in hearing about cool & cutting-edge research at MIT from excellent science communicators? Register to attend MIT’s first Research Slam Showcase\, a public showcase of research by MIT graduate students & scholars with prizes for the best communicators. The showcase will feature participants explaining their research and its importance in 3 minutes or less\, with judging by an expert panel of judges and by YOU\, the audience. \nThe 90-minute program will include live viewing of finalist Slam submissions\, evaluation & feedback from judges\, and a declaration of winners. Attendees can join in the fun by asking questions to participants\, leaving comments\, and voting for the audience-choice awards. So\, come join us for a celebration of innovative research and clear communication at MIT! \nThe Slam Showcase is free and open to everybody and anybody\, so please share with your friends & family. You can find more information at researchslam.mit.edu\, and please don’t hesitate to contact us with any questions! \nRegister to attend at: https://mit.zoom.us/webinar/register/WN_hI6g1uIxQh6xAWchqpkV1w
URL:https://scienceinboston.com/event/mit-research-slam-competition-public-showcase-2/
LOCATION:Online
ATTACH;FMTTYPE=image/png:https://scienceinboston.com/wp-content/uploads/sites/6/2021/03/3MT-Research-Slam-Logo-Final.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20210325T160000
DTEND;TZID=America/New_York:20210325T170000
DTSTAMP:20260621T031653
CREATED:20210322T175109Z
LAST-MODIFIED:20210322T175109Z
UID:13479-1616688000-1616691600@scienceinboston.com
SUMMARY:Dental Regenerative Medicine: Advancing Science to Help Patients
DESCRIPTION:William V. Giannobile \nDean\, Harvard School of Dental Medicine \nDr. William Giannobile\, dean of Harvard School of Dental Medicine (HSDM)\, is a leader in the field of periodontology and an internationally recognized scholar in oral regenerative medicine\, tissue engineering\, and precision medicine. He is an alumnus of HSDM\, with an advanced degree in periodontology and oral biology. \nThis talk will highlight tissue engineering strategies using biologics\, cellular and gene therapeutics that are now beginning to enter the clinical arena. These technologies include the use of 3D printing on growth factors to rebuild tissues around teeth and replacements in the jaws such as dental implants. \nHOST: \nDavid J. Mooney\, PhD \nFounding Core Faculty & Lead\, \nImmuno-Materials\, Wyss Institute at Harvard University; \nRobert P. Pinkas Family Professor of Bioengineering\, \nHarvard John A. Paulson School of Engineering and Applied Sciences
URL:https://scienceinboston.com/event/dental-regenerative-medicine-advancing-science-to-help-patients/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20210325T160000
DTEND;TZID=America/New_York:20210325T170000
DTSTAMP:20260621T031653
CREATED:20210322T175109Z
LAST-MODIFIED:20210322T175109Z
UID:27677-1616688000-1616691600@scienceinboston.com
SUMMARY:Dental Regenerative Medicine: Advancing Science to Help Patients
DESCRIPTION:William V. Giannobile \nDean\, Harvard School of Dental Medicine \nDr. William Giannobile\, dean of Harvard School of Dental Medicine (HSDM)\, is a leader in the field of periodontology and an internationally recognized scholar in oral regenerative medicine\, tissue engineering\, and precision medicine. He is an alumnus of HSDM\, with an advanced degree in periodontology and oral biology. \nThis talk will highlight tissue engineering strategies using biologics\, cellular and gene therapeutics that are now beginning to enter the clinical arena. These technologies include the use of 3D printing on growth factors to rebuild tissues around teeth and replacements in the jaws such as dental implants. \nHOST: \nDavid J. Mooney\, PhD \nFounding Core Faculty & Lead\, \nImmuno-Materials\, Wyss Institute at Harvard University; \nRobert P. Pinkas Family Professor of Bioengineering\, \nHarvard John A. Paulson School of Engineering and Applied Sciences
URL:https://scienceinboston.com/event/dental-regenerative-medicine-advancing-science-to-help-patients-2/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20210324T170000
DTEND;TZID=America/Vancouver:20210324T180000
DTSTAMP:20260621T031653
CREATED:20210301T181051Z
LAST-MODIFIED:20210301T181051Z
UID:13142-1616605200-1616608800@scienceinboston.com
SUMMARY:Biomedical Informatics Entrepreneurs Salon
DESCRIPTION:When\nWednesday\, March 24\, 2021\, 5 – 6pm\n\n\nWhere\nZoom\n\n\nSpeaker Name\nLevi Garraway\n\n\nSpeaker Title\nChief Medical Officer\n\n\nSpeaker Institution\nRoche and Genentech\n\n\nSpeaker Website\nwww.roche.com…\n\n\nRSVP Required\nYes\n\n\nDepartment/Office\nBiomedical Informatics\, Office of Technology Development\n\n\n\n\n\n\nDetails\n\nBIES is a monthly conversation about medicine\, biology\, computers\, and entrepreneurship. \nRegistration and more info to come!
URL:https://scienceinboston.com/event/biomedical-informatics-entrepreneurs-salon/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20210324T170000
DTEND;TZID=America/Vancouver:20210324T180000
DTSTAMP:20260621T031653
CREATED:20210301T181051Z
LAST-MODIFIED:20210301T181051Z
UID:27664-1616605200-1616608800@scienceinboston.com
SUMMARY:Biomedical Informatics Entrepreneurs Salon
DESCRIPTION:When\nWednesday\, March 24\, 2021\, 5 – 6pm\n\n\nWhere\nZoom\n\n\nSpeaker Name\nLevi Garraway\n\n\nSpeaker Title\nChief Medical Officer\n\n\nSpeaker Institution\nRoche and Genentech\n\n\nSpeaker Website\nwww.roche.com…\n\n\nRSVP Required\nYes\n\n\nDepartment/Office\nBiomedical Informatics\, Office of Technology Development\n\n\n\n\n\n\nDetails\n\nBIES is a monthly conversation about medicine\, biology\, computers\, and entrepreneurship. \nRegistration and more info to come!
URL:https://scienceinboston.com/event/biomedical-informatics-entrepreneurs-salon-3/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20210323T160000
DTEND;TZID=America/Vancouver:20210323T170000
DTSTAMP:20260621T031653
CREATED:20210301T180239Z
LAST-MODIFIED:20210301T180239Z
UID:13131-1616515200-1616518800@scienceinboston.com
SUMMARY:Biology Colloquium Series
DESCRIPTION:Speaker: Dr. Melanie Ott\, Gladstone Institute. \nHosted by: Laurie Boyer. \nTitle: “New approaches to testing and treating SARS-CoV-2” . \nThe Biology Colloquium is a weekly seminar held throughout the academic year\, featuring distinguished speakers in many areas of the biological sciences\, from universities and institutions worldwide. More information on speakers\, their affiliations\, and titles of their talks will be added as available. The Colloquium will zoom at 4:00PM  Tuesdays during the school year. Contact: Linda Earle lkn@mit.edu
URL:https://scienceinboston.com/event/biology-colloquium-series-2/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20210323T160000
DTEND;TZID=America/Vancouver:20210323T170000
DTSTAMP:20260621T031653
CREATED:20210301T180239Z
LAST-MODIFIED:20210301T180239Z
UID:27661-1616515200-1616518800@scienceinboston.com
SUMMARY:Biology Colloquium Series
DESCRIPTION:Speaker: Dr. Melanie Ott\, Gladstone Institute. \nHosted by: Laurie Boyer. \nTitle: “New approaches to testing and treating SARS-CoV-2” . \nThe Biology Colloquium is a weekly seminar held throughout the academic year\, featuring distinguished speakers in many areas of the biological sciences\, from universities and institutions worldwide. More information on speakers\, their affiliations\, and titles of their talks will be added as available. The Colloquium will zoom at 4:00PM  Tuesdays during the school year. Contact: Linda Earle lkn@mit.edu
URL:https://scienceinboston.com/event/biology-colloquium-series-2-2/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20210322T160000
DTEND;TZID=America/Vancouver:20210322T170000
DTSTAMP:20260621T031653
CREATED:20210301T180138Z
LAST-MODIFIED:20210301T180138Z
UID:13128-1616428800-1616432400@scienceinboston.com
SUMMARY:2021 Phillip A. Sharp Lecture in Neural Circuits
DESCRIPTION:Abstract: Both computational and experimental results in single neurons and small networks demonstrate that very similar network function can result from quite disparate sets of neuronal and network parameters.  Using the crustacean stomatogastric nervous system\, we now study the influence of these differences in underlying structure on differential resilience of individuals to a variety of environmental perturbations\, including changes in temperature\, pH\, potassium concentration and neuromodulation.  We show that neurons with many different kinds of ion channels can smoothly move through different mechanisms in generating their activity patterns\, thus extending their dynamic range. \nBiography: Eve Marder is currently the Victor and Gwendolyn Beinfield Professor of Neuroscience at Brandeis University. Her research gave key insights into rhythmic motor pattern generation\, neuromodulation\, homeostatic regulation of neurons and networks\, and the use of the dynamic clamp. Marder is a past president of the Society for Neuroscience\, and a member of the National Academy of Sciences\, the American Academy of Sciences\, and a fellow of the American Association for the Advancement of Science and the Biophysical Society. Marder is also a member of the Institute of Medicine’s Neuroscience Forum and a member of the National Advisory Neurological Disorders and Stroke (NANDS) Council. \nRegister in advance for this webinar:\nhttps://mit.zoom.us/webinar/register/WN_uNARVdP7Q_ORbx0MohGtPQ
URL:https://scienceinboston.com/event/2021-phillip-a-sharp-lecture-in-neural-circuits/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20210322T160000
DTEND;TZID=America/Vancouver:20210322T170000
DTSTAMP:20260621T031653
CREATED:20210301T180138Z
LAST-MODIFIED:20210301T180138Z
UID:27660-1616428800-1616432400@scienceinboston.com
SUMMARY:2021 Phillip A. Sharp Lecture in Neural Circuits
DESCRIPTION:Abstract: Both computational and experimental results in single neurons and small networks demonstrate that very similar network function can result from quite disparate sets of neuronal and network parameters.  Using the crustacean stomatogastric nervous system\, we now study the influence of these differences in underlying structure on differential resilience of individuals to a variety of environmental perturbations\, including changes in temperature\, pH\, potassium concentration and neuromodulation.  We show that neurons with many different kinds of ion channels can smoothly move through different mechanisms in generating their activity patterns\, thus extending their dynamic range. \nBiography: Eve Marder is currently the Victor and Gwendolyn Beinfield Professor of Neuroscience at Brandeis University. Her research gave key insights into rhythmic motor pattern generation\, neuromodulation\, homeostatic regulation of neurons and networks\, and the use of the dynamic clamp. Marder is a past president of the Society for Neuroscience\, and a member of the National Academy of Sciences\, the American Academy of Sciences\, and a fellow of the American Association for the Advancement of Science and the Biophysical Society. Marder is also a member of the Institute of Medicine’s Neuroscience Forum and a member of the National Advisory Neurological Disorders and Stroke (NANDS) Council. \nRegister in advance for this webinar:\nhttps://mit.zoom.us/webinar/register/WN_uNARVdP7Q_ORbx0MohGtPQ
URL:https://scienceinboston.com/event/2021-phillip-a-sharp-lecture-in-neural-circuits-2/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20210319T190000
DTEND;TZID=America/New_York:20210319T200000
DTSTAMP:20260621T031653
CREATED:20210319T180857Z
LAST-MODIFIED:20210319T180857Z
UID:13454-1616180400-1616184000@scienceinboston.com
SUMMARY:Pioneering Medicines and Health Security with Noubar Afeyan
DESCRIPTION:You are invited to join Ruth Lehmann\, President and Director of Whitehead Institute\, for a series of virtual dialogues with scientific luminaries from academia\, and visionary leaders from the biotech industry. \nWhat trends in science and technology excite them the most? Which innovations have the potential to dramatically impact the way we live and work? \nBe a part of the conversation.
URL:https://scienceinboston.com/event/pioneering-medicines-and-health-security-with-noubar-afeyan/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20210319T190000
DTEND;TZID=America/New_York:20210319T200000
DTSTAMP:20260621T031653
CREATED:20210319T180857Z
LAST-MODIFIED:20210319T180857Z
UID:27675-1616180400-1616184000@scienceinboston.com
SUMMARY:Pioneering Medicines and Health Security with Noubar Afeyan
DESCRIPTION:You are invited to join Ruth Lehmann\, President and Director of Whitehead Institute\, for a series of virtual dialogues with scientific luminaries from academia\, and visionary leaders from the biotech industry. \nWhat trends in science and technology excite them the most? Which innovations have the potential to dramatically impact the way we live and work? \nBe a part of the conversation.
URL:https://scienceinboston.com/event/pioneering-medicines-and-health-security-with-noubar-afeyan-2/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20210318T110000
DTEND;TZID=America/Vancouver:20210318T120000
DTSTAMP:20260621T031653
CREATED:20210315T154828Z
LAST-MODIFIED:20210315T154828Z
UID:13365-1616065200-1616068800@scienceinboston.com
SUMMARY:MassBio Virtual Speed Networking
DESCRIPTION:Join MassBio for a Virtual Speed Networking Mixer! If you want to grow your network\, meet others individually and do not have the time for a long event\, then this virtual mixer is perfect for you. There will be short rounds of one-on-one networking with a different person assigned each rotation. Leave the event with new connections all under 1 hour! \nAttendeess will be entered into a raffle to win a $50 gift card to Gather in the Seaport District. \nFree for MassBio Members. Registration is required. \nTo inquire about sponsorship opportunities\, contact Lea Cherchia or Jessica Sousa. \nMassBio makes every effort to accommodate our entire community at each of our events. Please let us know at least 3 days in advance of the event if you require special accommodations\, such as captioning.
URL:https://scienceinboston.com/event/massbio-virtual-speed-networking/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20210318T110000
DTEND;TZID=America/Vancouver:20210318T120000
DTSTAMP:20260621T031653
CREATED:20210315T154828Z
LAST-MODIFIED:20210315T154828Z
UID:27672-1616065200-1616068800@scienceinboston.com
SUMMARY:MassBio Virtual Speed Networking
DESCRIPTION:Join MassBio for a Virtual Speed Networking Mixer! If you want to grow your network\, meet others individually and do not have the time for a long event\, then this virtual mixer is perfect for you. There will be short rounds of one-on-one networking with a different person assigned each rotation. Leave the event with new connections all under 1 hour! \nAttendeess will be entered into a raffle to win a $50 gift card to Gather in the Seaport District. \nFree for MassBio Members. Registration is required. \nTo inquire about sponsorship opportunities\, contact Lea Cherchia or Jessica Sousa. \nMassBio makes every effort to accommodate our entire community at each of our events. Please let us know at least 3 days in advance of the event if you require special accommodations\, such as captioning.
URL:https://scienceinboston.com/event/massbio-virtual-speed-networking-2/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20210317T130000
DTEND;TZID=America/Vancouver:20210317T140000
DTSTAMP:20260621T031653
CREATED:20210301T181913Z
LAST-MODIFIED:20210301T181913Z
UID:13162-1615986000-1615989600@scienceinboston.com
SUMMARY:Find New Leads from Peptides and Natural Ligands
DESCRIPTION:Virtual screening can be a very efficient way to identify initial lead molecules or a back-up series for a drug discovery program. Obvious advantages include access to increased molecular diversity\, an ability to find new IP\, savings in time and ultimately cost. One of the most critical challenges of virtual screening is determining the most effective screening strategy: this implies working through the data and detail of the experimental design to achieve the desired outcome for any given starting point. \nIn this webinar we will show how Flare™\, Forge™ and Blaze™ can be used to analyze and develop an appropriate virtual screening strategy for complex target systems for which no simple small ligands exists\, and how that can be worked into an effective virtual screen.
URL:https://scienceinboston.com/event/find-new-leads-from-peptides-and-natural-ligands/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20210317T130000
DTEND;TZID=America/Vancouver:20210317T140000
DTSTAMP:20260621T031653
CREATED:20210301T181913Z
LAST-MODIFIED:20210301T181913Z
UID:27669-1615986000-1615989600@scienceinboston.com
SUMMARY:Find New Leads from Peptides and Natural Ligands
DESCRIPTION:Virtual screening can be a very efficient way to identify initial lead molecules or a back-up series for a drug discovery program. Obvious advantages include access to increased molecular diversity\, an ability to find new IP\, savings in time and ultimately cost. One of the most critical challenges of virtual screening is determining the most effective screening strategy: this implies working through the data and detail of the experimental design to achieve the desired outcome for any given starting point. \nIn this webinar we will show how Flare™\, Forge™ and Blaze™ can be used to analyze and develop an appropriate virtual screening strategy for complex target systems for which no simple small ligands exists\, and how that can be worked into an effective virtual screen.
URL:https://scienceinboston.com/event/find-new-leads-from-peptides-and-natural-ligands-2/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20210316T130000
DTEND;TZID=America/Vancouver:20210316T140000
DTSTAMP:20260621T031653
CREATED:20210301T180931Z
LAST-MODIFIED:20210301T180931Z
UID:13137-1615899600-1615903200@scienceinboston.com
SUMMARY:Interdisciplinary Neuroscience Colloquia of Extramural Postdoctoral Talks
DESCRIPTION:INCEPT —Interdisciplinary Neuroscience Colloquia of Extramural Postdoctoral Talks\, is a new talk series organized by the INCEPT committee of Neurobio Postdoc Club to provide exceptional senior postdocs with more opportunities to receive feedback and practice their prospective job talks. \nSpeaker: Dr. DelSignore\nTopic: Organization and regulation of synaptic endocytic machinery \nThe synaptic endocytic machinery regulates the traffic of cargoes important for synaptic development\, activity\, and plasticity\, and defects in this machinery are associated with a variety of neurological diseases. Unlike non-neuronal cells\, in which endocytic machinery assembles transiently at discrete 50-100nm sites of endocytosis\, the synaptic endocytic machinery assembles persistently at membranes in a poorly understood micron scale domain called the ‘Periactive Zone (PAZ)’\, within which active endocytic events occur sparsely in space and time. This suggests that there are neuron-specific mechanisms to broadly organize and then locally activate this machinery. Problem: How does micron-scale PAZ machinery direct nano-scale endocytic events? \nWe previously found that the PAZ protein Nervous Wreck couples membrane remodeling to force-generating actin assembly\, but is locked in an autoinhibited state even after it associates with membranes. I hypothesized that local relief of autoregulation could promote discrete membrane remodeling events. Using in vitro assays\, I found that SH3-mediated interactions among Nervous Wreck\, the actin assembly factor WASp\, and the scaffold Dap160/Intersectin cooperate to fully relieve autoinhibition of membrane binding and actin assembly. To test how this mechanism regulates synaptic endocytosis\, I developed novel methods at the Drosophila neuromuscular junction to quantify PAZ activation by quantitative live imaging of actin assembly\, and PAZ organization by super-resolution microscopy. I found that loss of Nervous Wreck\, Dap160\, or their interaction resulted in short-lived\, likely unproductive actin assembly\, and compromised synaptic endocytosis. In currently ongoing work\, I am further investigating the mechanisms that organize PAZ micron-scale architecture. I find that the same SH3 interactions that promote PAZ activation are also required for its micron-scale architecture at synapses\, and drive phase separation in vitro\, suggesting a biochemical mechanism for micron-scale assembly. This raises the exciting question of how phase separation and autoregulation might collaboratively organize PAZ architecture and function.\nSocial for postdocs and students to follow. \nPlease email neurobiopostoc@gmail.com for all zoom links
URL:https://scienceinboston.com/event/interdisciplinary-neuroscience-colloquia-of-extramural-postdoctoral-talks/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20210316T130000
DTEND;TZID=America/Vancouver:20210316T140000
DTSTAMP:20260621T031653
CREATED:20210301T180931Z
LAST-MODIFIED:20210301T180931Z
UID:27663-1615899600-1615903200@scienceinboston.com
SUMMARY:Interdisciplinary Neuroscience Colloquia of Extramural Postdoctoral Talks
DESCRIPTION:INCEPT —Interdisciplinary Neuroscience Colloquia of Extramural Postdoctoral Talks\, is a new talk series organized by the INCEPT committee of Neurobio Postdoc Club to provide exceptional senior postdocs with more opportunities to receive feedback and practice their prospective job talks. \nSpeaker: Dr. DelSignore\nTopic: Organization and regulation of synaptic endocytic machinery \nThe synaptic endocytic machinery regulates the traffic of cargoes important for synaptic development\, activity\, and plasticity\, and defects in this machinery are associated with a variety of neurological diseases. Unlike non-neuronal cells\, in which endocytic machinery assembles transiently at discrete 50-100nm sites of endocytosis\, the synaptic endocytic machinery assembles persistently at membranes in a poorly understood micron scale domain called the ‘Periactive Zone (PAZ)’\, within which active endocytic events occur sparsely in space and time. This suggests that there are neuron-specific mechanisms to broadly organize and then locally activate this machinery. Problem: How does micron-scale PAZ machinery direct nano-scale endocytic events? \nWe previously found that the PAZ protein Nervous Wreck couples membrane remodeling to force-generating actin assembly\, but is locked in an autoinhibited state even after it associates with membranes. I hypothesized that local relief of autoregulation could promote discrete membrane remodeling events. Using in vitro assays\, I found that SH3-mediated interactions among Nervous Wreck\, the actin assembly factor WASp\, and the scaffold Dap160/Intersectin cooperate to fully relieve autoinhibition of membrane binding and actin assembly. To test how this mechanism regulates synaptic endocytosis\, I developed novel methods at the Drosophila neuromuscular junction to quantify PAZ activation by quantitative live imaging of actin assembly\, and PAZ organization by super-resolution microscopy. I found that loss of Nervous Wreck\, Dap160\, or their interaction resulted in short-lived\, likely unproductive actin assembly\, and compromised synaptic endocytosis. In currently ongoing work\, I am further investigating the mechanisms that organize PAZ micron-scale architecture. I find that the same SH3 interactions that promote PAZ activation are also required for its micron-scale architecture at synapses\, and drive phase separation in vitro\, suggesting a biochemical mechanism for micron-scale assembly. This raises the exciting question of how phase separation and autoregulation might collaboratively organize PAZ architecture and function.\nSocial for postdocs and students to follow. \nPlease email neurobiopostoc@gmail.com for all zoom links
URL:https://scienceinboston.com/event/interdisciplinary-neuroscience-colloquia-of-extramural-postdoctoral-talks-2/
LOCATION:Online
END:VEVENT
END:VCALENDAR