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DTSTART;TZID=America/New_York:20190926T163000
DTEND;TZID=America/New_York:20190926T210000
DTSTAMP:20190909T145118Z
CREATED:20190909T145118Z
LAST-MODIFIED:20190909T145118Z
UID:27332-1569515400-1569531600@scienceinboston.com
SUMMARY:Protecting Intellectual Property in Pharmaceuticals
DESCRIPTION:Description\nSeptember 2019 Monthly Meeting of NESACS\nThis meeting will be hosted by Biogen \nProtecting Intellectual Property in Pharmaceuticals\nPlease join us for our September Monthly meeting to honor our 50\, 60\, and 70 year members. This month’s meeting will focus on considerations and strategies toward protecting intellectual property in pharma and biotech. The Panel will be moderated by Sofia Santos\, PharmD\, PhD\, of Finnegan LLP. Panelists will include: \n\nEmilie Braun\, PharmD\, Associate Director\, Licensing\, Partners Healthcare Innovation\nSara Leiman\, PhD\, Associate\, Finnegan LLP\, Boston\, MA\nJennifer (Sieczkiewicz) Zarutskie\, PhD\, Vice President\, Chief Intellectual Property Counsel at Wave Life Sciences\nTBA\, Biogen\n\nWe want to thank Biogen and Finnegan LLP for their support of this event. Please check-in with security at Building 9 and you will be escorted in for the meeting. \n4:30 pm – 5.30 pm NESACS Board Meeting – (Building 9) \n5:30 pm – 6:30 pm Social Hour – Building 8 Atrium \n6:30 pm – 7:30 pm Dinner – Building 8 Auditorium \n7:30 pm – 9:00 pm Presentation of 50\, 60\, and 70 year member awards and Discussion Panel on Intellectual Property \nYOU MUST REGISTER IN ADVANCE TO ATTEND THE MEETING: THERE IS NO REGISTRATION FEE \nTO ATTEND THE MEETING; DINNER RESERVATIONS ARE REQUIRED. PUBLIC IS INVITED \n\nFor those who would like to join us for dinner\, register by noon\, Thursday\, September 19\, at https://intellectual_property_2019.eventbrite.com.\nCost: Members\, $30; Non-members\, $35; Retirees\, $20; Students\, $10. Dinner reservations not cancelled at least 24 hours will not be refunded. If you wish to join us for this meeting and not eat dinner\, please register by noon\, Thursday\, September 19\, at https://intellectual_property_2019.eventbrite.com. Select “Seminar only”.\nDirections to Biogen – 300 Binney Street – BLDG 9\, Cambridge\, MA 02142; (617) 679-2000. Please park in “Blue” parking lot.\n\nMBTA: \n\nTake the Red Line T to the “Kendall Square/MIT” stop.\nWalk up the stairs and locate the Marriott Hotel entrance.\nWalk through the lobby of the Marriott Hotel to Broadway Street.\nRefer to the detailed map\, on last page\, for exact location.\n\nFrom Highways North or South: \n\nTake 93 North or South.\nExit #26 (Storrow Drive).\nTake Storrow Drive\, take the first left to “Government Center/ Kendall Square”.\nGo up the ramp and turn right over the Longfellow Bridge.\nGo straight and pass the Marriott Cambridge Hotel on the left.\nBiogen locations are on your right\, just after the Ames Street intersection.\nParking can be accessed via the 2nd driveway on right.\nBiogen locations are across the street from the side exit of the parking garage.\n\nFrom West: \n\nTake I-90/Massachusetts Turnpike/Mass Pike East (towards Boston).\nExit #18 (Allston/Cambridge).\nAfter toll bear right toward “Cambridge/ Somerville”.\nTurn right onto Storrow Drive (Guest Quarters Suite Hotel is on your right).\nExit (Government Center/Kendall Square).\nGo around the rotary until you see the entry ramp for the Longfellow Bridge.\nGo over the Longfellow Bridge.\nGo straight and you will pass the Marriott Cambridge Hotel on the left.\nBiogen locations are on your right\, just after the Ames Street intersection.\nParking can be accessed via the 2nd driveway on right.\nBiogen locations are across the street from the side exit of the parking garage.\n\nQuestions? Please contact: Ms. Anna Singer during regular business hours\, secretary@nesacs.org. \nTHE PUBLIC IS INVITED – RESERVATIONS ARE REQUIRED \nRegistration is required and an ID will be required to enter the Biogen facility. Parking is available on-site. \nRegistration or other questions? Please contact: Ms. Anna Singer during regular business hours\, secretary@nesacs.org. \nFAQs \nWhat time does the innovation panel start? \nThe panel discussion will begin after dinner around 7:30 PM. \nWhat are my transport/parking options getting to the event? \nParking is available on-site. \nFor driving directions from where you will begin your trip\, enter “300 Binney Street\, Cambridge\, MA” into your mapping app or GPS. \nWhere can I contact the organizer with any questions? \nWith any questions whatsoever\, please contact Ms. Anna Singer\, secretary@nesacs.org \nIs my registration/ticket transferrable? \nYes\, please contact Ms. Anna Singer\, secretary@nesacs.org\, before September 19\, 2019.
URL:https://scienceinboston.com/event/protecting-intellectual-property-in-pharmaceuticals-2/
LOCATION:Biogen\, 300 Binney Street\, Cambridge\, MA\, 02142\, United States
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20190926T163000
DTEND;TZID=America/New_York:20190926T210000
DTSTAMP:20190909T145118Z
CREATED:20190909T145118Z
LAST-MODIFIED:20190909T145118Z
UID:6436-1569515400-1569531600@scienceinboston.com
SUMMARY:Protecting Intellectual Property in Pharmaceuticals
DESCRIPTION:Description\nSeptember 2019 Monthly Meeting of NESACS\nThis meeting will be hosted by Biogen \nProtecting Intellectual Property in Pharmaceuticals\nPlease join us for our September Monthly meeting to honor our 50\, 60\, and 70 year members. This month’s meeting will focus on considerations and strategies toward protecting intellectual property in pharma and biotech. The Panel will be moderated by Sofia Santos\, PharmD\, PhD\, of Finnegan LLP. Panelists will include: \n\nEmilie Braun\, PharmD\, Associate Director\, Licensing\, Partners Healthcare Innovation\nSara Leiman\, PhD\, Associate\, Finnegan LLP\, Boston\, MA\nJennifer (Sieczkiewicz) Zarutskie\, PhD\, Vice President\, Chief Intellectual Property Counsel at Wave Life Sciences\nTBA\, Biogen\n\nWe want to thank Biogen and Finnegan LLP for their support of this event. Please check-in with security at Building 9 and you will be escorted in for the meeting. \n4:30 pm – 5.30 pm NESACS Board Meeting – (Building 9) \n5:30 pm – 6:30 pm Social Hour – Building 8 Atrium \n6:30 pm – 7:30 pm Dinner – Building 8 Auditorium \n7:30 pm – 9:00 pm Presentation of 50\, 60\, and 70 year member awards and Discussion Panel on Intellectual Property \nYOU MUST REGISTER IN ADVANCE TO ATTEND THE MEETING: THERE IS NO REGISTRATION FEE \nTO ATTEND THE MEETING; DINNER RESERVATIONS ARE REQUIRED. PUBLIC IS INVITED \n\nFor those who would like to join us for dinner\, register by noon\, Thursday\, September 19\, at https://intellectual_property_2019.eventbrite.com.\nCost: Members\, $30; Non-members\, $35; Retirees\, $20; Students\, $10. Dinner reservations not cancelled at least 24 hours will not be refunded. If you wish to join us for this meeting and not eat dinner\, please register by noon\, Thursday\, September 19\, at https://intellectual_property_2019.eventbrite.com. Select “Seminar only”.\nDirections to Biogen – 300 Binney Street – BLDG 9\, Cambridge\, MA 02142; (617) 679-2000. Please park in “Blue” parking lot.\n\nMBTA: \n\nTake the Red Line T to the “Kendall Square/MIT” stop.\nWalk up the stairs and locate the Marriott Hotel entrance.\nWalk through the lobby of the Marriott Hotel to Broadway Street.\nRefer to the detailed map\, on last page\, for exact location.\n\nFrom Highways North or South: \n\nTake 93 North or South.\nExit #26 (Storrow Drive).\nTake Storrow Drive\, take the first left to “Government Center/ Kendall Square”.\nGo up the ramp and turn right over the Longfellow Bridge.\nGo straight and pass the Marriott Cambridge Hotel on the left.\nBiogen locations are on your right\, just after the Ames Street intersection.\nParking can be accessed via the 2nd driveway on right.\nBiogen locations are across the street from the side exit of the parking garage.\n\nFrom West: \n\nTake I-90/Massachusetts Turnpike/Mass Pike East (towards Boston).\nExit #18 (Allston/Cambridge).\nAfter toll bear right toward “Cambridge/ Somerville”.\nTurn right onto Storrow Drive (Guest Quarters Suite Hotel is on your right).\nExit (Government Center/Kendall Square).\nGo around the rotary until you see the entry ramp for the Longfellow Bridge.\nGo over the Longfellow Bridge.\nGo straight and you will pass the Marriott Cambridge Hotel on the left.\nBiogen locations are on your right\, just after the Ames Street intersection.\nParking can be accessed via the 2nd driveway on right.\nBiogen locations are across the street from the side exit of the parking garage.\n\nQuestions? Please contact: Ms. Anna Singer during regular business hours\, secretary@nesacs.org. \nTHE PUBLIC IS INVITED – RESERVATIONS ARE REQUIRED \nRegistration is required and an ID will be required to enter the Biogen facility. Parking is available on-site. \nRegistration or other questions? Please contact: Ms. Anna Singer during regular business hours\, secretary@nesacs.org. \nFAQs \nWhat time does the innovation panel start? \nThe panel discussion will begin after dinner around 7:30 PM. \nWhat are my transport/parking options getting to the event? \nParking is available on-site. \nFor driving directions from where you will begin your trip\, enter “300 Binney Street\, Cambridge\, MA” into your mapping app or GPS. \nWhere can I contact the organizer with any questions? \nWith any questions whatsoever\, please contact Ms. Anna Singer\, secretary@nesacs.org \nIs my registration/ticket transferrable? \nYes\, please contact Ms. Anna Singer\, secretary@nesacs.org\, before September 19\, 2019.
URL:https://scienceinboston.com/event/protecting-intellectual-property-in-pharmaceuticals/
LOCATION:Biogen\, 300 Binney Street\, Cambridge\, MA\, 02142\, United States
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20190920T113000
DTEND;TZID=America/New_York:20190920T130000
DTSTAMP:20190909T144857Z
CREATED:20190909T144857Z
LAST-MODIFIED:20190909T144857Z
UID:6433-1568979000-1568984400@scienceinboston.com
SUMMARY:Lunch & Learn: New Exosome Isolation Method and Its Applications
DESCRIPTION:Description\n\n\n\nLunch & Learn: New exosome isolation method and its applications \nExosomes are in the spotlight of drug delivery research\, diagnostic and new therapy development. Once thought to be merely carriers of unnecessary cell content\, exosomes are now known to regulate cell-cell communication\, transporting lipids\, proteins\, and RNA. Isolating exosomes can be\, however\, cumbersome\, and traditional centrifugation methods often result in poor yield and low purity. \nAddressing these needs in life science research\, FUJIFILM Wako has developed a novel method for isolating Exosome by using Tim-4/PS affinity method. In this seminar\, Wako introduces its MagCapture™ product line\, as well as scientific findings by using this technology. \nParticipants will have opportunities to; \n\nLearn how MagCapture™ Exosome Isolation Kit enables isolation and purification of exosomes with four simple steps\nSee case studies demonstrating the data obtained using MagCapture™ products\nJoin in a user community for discussion and Q&A\n\n11:30-12:00 \nRegistration\n12:00-12:40 \nExtracellular vesicles (EVs) from human bone marrow mesenchymal stem cells (hBM-MSCs) repair organ damage caused by cadmium (Cd) poisoning in a medaka model\nPresenter: \nTomoko Obara\, Ph. D.\nDepartment of Cell Biology\, University of Oklahoma Health Sciences Center\, Oklahoma City\, OK\, USA\nAbstract: \nBecause chronic exposure to heavy metal is undiagnosed in the early stages\, the chelation therapy is ineffective. EVs derived from stem cells have been demonstrated to reduce disease pathology in both acute and chronic kidney disease models. To test the ability of EVs derived from hBM-MSCs to treat Cd damage\, we generated a Cd-exposed medaka model. This model develops Cd-induced cell damage of various organs and tissues\, and shows decreased survival. Intravenous injection of highly purified EVs from hBM-MSCs repaired the damage to kidney proximal tubules\, glomerulus podocytes\, repaired bone deformation\, and improved survival. In addition to the Cd injury repair\, our system also serves as a model with which to study age- and sex-dependent cell injuries of organs caused by other various agents and diseases. The beneficial effects of EVs on the tissue repair process\, as shown in our novel Cd-exposed medaka model\, may open new broad avenues for interventional strategies.\n12:40-13:00 \nCharacteristics on PS Affinity for Isolation and Detection of EVs: Advantages Clarified from Comparison with Conventional Methods\nPresenter: \nSadamu Ozaki\, FUJIFILM Wako Pure Chemical Corporation\nAbstract: \nFUJIFILM Wako introduces a novel affinity purification method using Tim4 for isolating and detecting extracellular vesicles (EVs). Our new method enables easy isolation of high purity and high yield EVs from cell culture medium and body fluids\, without ultracentrifugation. In this seminar\, we will introduce the main features of PS Affinity.\nA light lunch will be served.
URL:https://scienceinboston.com/event/lunch-learn-new-exosome-isolation-method-and-its-applications/
LOCATION:FUJIFILM Diosynth Cambridge Collaboration Center (C3)\, One Kendall Square\, Binney St\, Building 400\, Cambridge\, MA\, 02139\, United States
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20190920T113000
DTEND;TZID=America/New_York:20190920T130000
DTSTAMP:20190909T144857Z
CREATED:20190909T144857Z
LAST-MODIFIED:20190909T144857Z
UID:27331-1568979000-1568984400@scienceinboston.com
SUMMARY:Lunch & Learn: New Exosome Isolation Method and Its Applications
DESCRIPTION:Description\n\n\n\nLunch & Learn: New exosome isolation method and its applications \nExosomes are in the spotlight of drug delivery research\, diagnostic and new therapy development. Once thought to be merely carriers of unnecessary cell content\, exosomes are now known to regulate cell-cell communication\, transporting lipids\, proteins\, and RNA. Isolating exosomes can be\, however\, cumbersome\, and traditional centrifugation methods often result in poor yield and low purity. \nAddressing these needs in life science research\, FUJIFILM Wako has developed a novel method for isolating Exosome by using Tim-4/PS affinity method. In this seminar\, Wako introduces its MagCapture™ product line\, as well as scientific findings by using this technology. \nParticipants will have opportunities to; \n\nLearn how MagCapture™ Exosome Isolation Kit enables isolation and purification of exosomes with four simple steps\nSee case studies demonstrating the data obtained using MagCapture™ products\nJoin in a user community for discussion and Q&A\n\n11:30-12:00 \nRegistration\n12:00-12:40 \nExtracellular vesicles (EVs) from human bone marrow mesenchymal stem cells (hBM-MSCs) repair organ damage caused by cadmium (Cd) poisoning in a medaka model\nPresenter: \nTomoko Obara\, Ph. D.\nDepartment of Cell Biology\, University of Oklahoma Health Sciences Center\, Oklahoma City\, OK\, USA\nAbstract: \nBecause chronic exposure to heavy metal is undiagnosed in the early stages\, the chelation therapy is ineffective. EVs derived from stem cells have been demonstrated to reduce disease pathology in both acute and chronic kidney disease models. To test the ability of EVs derived from hBM-MSCs to treat Cd damage\, we generated a Cd-exposed medaka model. This model develops Cd-induced cell damage of various organs and tissues\, and shows decreased survival. Intravenous injection of highly purified EVs from hBM-MSCs repaired the damage to kidney proximal tubules\, glomerulus podocytes\, repaired bone deformation\, and improved survival. In addition to the Cd injury repair\, our system also serves as a model with which to study age- and sex-dependent cell injuries of organs caused by other various agents and diseases. The beneficial effects of EVs on the tissue repair process\, as shown in our novel Cd-exposed medaka model\, may open new broad avenues for interventional strategies.\n12:40-13:00 \nCharacteristics on PS Affinity for Isolation and Detection of EVs: Advantages Clarified from Comparison with Conventional Methods\nPresenter: \nSadamu Ozaki\, FUJIFILM Wako Pure Chemical Corporation\nAbstract: \nFUJIFILM Wako introduces a novel affinity purification method using Tim4 for isolating and detecting extracellular vesicles (EVs). Our new method enables easy isolation of high purity and high yield EVs from cell culture medium and body fluids\, without ultracentrifugation. In this seminar\, we will introduce the main features of PS Affinity.\nA light lunch will be served.
URL:https://scienceinboston.com/event/lunch-learn-new-exosome-isolation-method-and-its-applications-2/
LOCATION:FUJIFILM Diosynth Cambridge Collaboration Center (C3)\, One Kendall Square\, Binney St\, Building 400\, Cambridge\, MA\, 02139\, United States
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20190920T090000
DTEND;TZID=America/New_York:20190920T110000
DTSTAMP:20190909T143741Z
CREATED:20190909T143741Z
LAST-MODIFIED:20190909T143741Z
UID:27328-1568970000-1568977200@scienceinboston.com
SUMMARY:Strategies for Managing the Leachables Risk for Container Closure Systems
DESCRIPTION:Join Pine Lake Laboratories and Ph.D. Michael Ruberto to learn Strategies for Managing the Leachables Risk for Container Closure Systems!\n\n\n\n\n\n\nAbout this Event\n\n\nThis presentation will focus on key strategies to ensure compliance with the new series of USP chapters that cover extractables and leachables for container closure systems: USP 661.2\, 1663\, 1664 and how they correlate to following additional topics: \n\nA review of the PQRI “Best Practices” for performing E&L Testing\n\n\nNew PQRI recommendations for setting thresholds and calculating the Analytical Evaluation Threshold (AET)\n\n\nFDA Expectations for “high risk” and “low risk” dosage forms\n\n\nUsing the FDA food contact regulations for container closure system materials of construction to reduce or even eliminate E&L testing for oral and topical drug products\n\n\nPreparing an E&L materials assessment report to detail the strategies used in designing and performing the E&L testing\n\nDr. Michael Ruberto is a retained consultant to Pine Lake Laboratories available to support all extractable and leachable studies\, as well as the President of Material Needs Consulting\, LLC which provides consulting services to manage the development and commercialization of medical devices and packaging. Dr. Ruberto is an active member of various pharmaceutical groups that have developed “best practices” for characterizing and evaluating the safety of container closure systems. \nLight refreshments will be served prior to Dr. Ruberto’s presentation. We look forward to your attendance.
URL:https://scienceinboston.com/event/strategies-for-managing-the-leachables-risk-for-container-closure-systems-2/
LOCATION:MassBio\, 300 Technology Square 8th Fl\, Cambridge\, MA\, 02139\, United States
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20190920T090000
DTEND;TZID=America/New_York:20190920T110000
DTSTAMP:20190909T143741Z
CREATED:20190909T143741Z
LAST-MODIFIED:20190909T143741Z
UID:6427-1568970000-1568977200@scienceinboston.com
SUMMARY:Strategies for Managing the Leachables Risk for Container Closure Systems
DESCRIPTION:Join Pine Lake Laboratories and Ph.D. Michael Ruberto to learn Strategies for Managing the Leachables Risk for Container Closure Systems!\n\n\n\n\n\n\nAbout this Event\n\n\nThis presentation will focus on key strategies to ensure compliance with the new series of USP chapters that cover extractables and leachables for container closure systems: USP 661.2\, 1663\, 1664 and how they correlate to following additional topics: \n\nA review of the PQRI “Best Practices” for performing E&L Testing\n\n\nNew PQRI recommendations for setting thresholds and calculating the Analytical Evaluation Threshold (AET)\n\n\nFDA Expectations for “high risk” and “low risk” dosage forms\n\n\nUsing the FDA food contact regulations for container closure system materials of construction to reduce or even eliminate E&L testing for oral and topical drug products\n\n\nPreparing an E&L materials assessment report to detail the strategies used in designing and performing the E&L testing\n\nDr. Michael Ruberto is a retained consultant to Pine Lake Laboratories available to support all extractable and leachable studies\, as well as the President of Material Needs Consulting\, LLC which provides consulting services to manage the development and commercialization of medical devices and packaging. Dr. Ruberto is an active member of various pharmaceutical groups that have developed “best practices” for characterizing and evaluating the safety of container closure systems. \nLight refreshments will be served prior to Dr. Ruberto’s presentation. We look forward to your attendance.
URL:https://scienceinboston.com/event/strategies-for-managing-the-leachables-risk-for-container-closure-systems/
LOCATION:MassBio\, 300 Technology Square 8th Fl\, Cambridge\, MA\, 02139\, United States
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20190920T080000
DTEND;TZID=America/New_York:20190920T170000
DTSTAMP:20190816T143506Z
CREATED:20190816T143506Z
LAST-MODIFIED:20190816T143506Z
UID:27317-1568966400-1568998800@scienceinboston.com
SUMMARY:Targeting RNA: Expanding Therapeutic Biology
DESCRIPTION:This symposium will focus on the rapidly evolving field of RNA as a drug target for small molecules\, and key areas that will be discussed include \n\nAdvances in RNA biology and its role in human disease.\nApproaches for interrogating relevant RNA and RNA/protein structures\nStrategies for identifying small molecule lead matter for targeting RNA.\n\n  \nOur co-organisers Jeremy Baryza (Vertex)\,  Razvan Nutiu (Novartis) and Martin Pettersson (Pfizer) have put together an exciting array of talks. \n  \n  \nPlease register early to help with our logistsics and please do forward invite to those not on our mailing list. \n\n\nNESBA is a non-profit organisation run by volunteers\, please contact info@nesba.net to sponsor the event. \n\nThe fee for this one-day event will be $150 and includes breakfast\, lunch and a mixer session. \n\nFor sponsorship opportunities\, please visit:  http://nesba.net/sponsors.html
URL:https://scienceinboston.com/event/targeting-rna-expanding-therapeutic-biology-2/
LOCATION:Bentley University\, LaCava Center\, 175 Forest Street\, Waltham\, MA\, 02452\, United States
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20190920T080000
DTEND;TZID=America/New_York:20190920T170000
DTSTAMP:20190816T143506Z
CREATED:20190816T143506Z
LAST-MODIFIED:20190816T143506Z
UID:6212-1568966400-1568998800@scienceinboston.com
SUMMARY:Targeting RNA: Expanding Therapeutic Biology
DESCRIPTION:This symposium will focus on the rapidly evolving field of RNA as a drug target for small molecules\, and key areas that will be discussed include \n\nAdvances in RNA biology and its role in human disease.\nApproaches for interrogating relevant RNA and RNA/protein structures\nStrategies for identifying small molecule lead matter for targeting RNA.\n\n  \nOur co-organisers Jeremy Baryza (Vertex)\,  Razvan Nutiu (Novartis) and Martin Pettersson (Pfizer) have put together an exciting array of talks. \n  \n  \nPlease register early to help with our logistsics and please do forward invite to those not on our mailing list. \n\n\nNESBA is a non-profit organisation run by volunteers\, please contact info@nesba.net to sponsor the event. \n\nThe fee for this one-day event will be $150 and includes breakfast\, lunch and a mixer session. \n\nFor sponsorship opportunities\, please visit:  http://nesba.net/sponsors.html
URL:https://scienceinboston.com/event/targeting-rna-expanding-therapeutic-biology/
LOCATION:Bentley University\, LaCava Center\, 175 Forest Street\, Waltham\, MA\, 02452\, United States
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20190920T070000
DTEND;TZID=America/New_York:20190920T170000
DTSTAMP:20190815T153306Z
CREATED:20190815T153306Z
LAST-MODIFIED:20190815T153306Z
UID:27312-1568962800-1568998800@scienceinboston.com
SUMMARY:Next-Generation Diagnostics: 10th Annual International Symposium
DESCRIPTION:The 10th International Wyss Institute Symposium will focus on Next-Generation Diagnostics; convening the Institute’s vast network of collaborators\, students\, researchers\, faculty and clinicians alongside industrial researchers\, and members of academic institutions and foundations leading the development of diagnostics technology. This year’s Symposium will highlight the latest developments of this emerging field and address the need for more accurate\, rapid\, and lower cost diagnostic technologies to meet clinical challenges in hospitals\, in physician’s offices\, at home\, and at the point-of-care in both the developed and developing world. Presentations will focus on translation and accelerating the development and application of diagnostic technology toward commercial and clinical application.
URL:https://scienceinboston.com/event/next-generation-diagnostics-10th-annual-international-symposium-2/
LOCATION:Joseph B. Martin Conference Center\, 77 Avenue Louis Pasteur\, Boston\, MA\, 02115\, United States
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20190920T070000
DTEND;TZID=America/New_York:20190920T170000
DTSTAMP:20190815T153306Z
CREATED:20190815T153306Z
LAST-MODIFIED:20190815T153306Z
UID:6194-1568962800-1568998800@scienceinboston.com
SUMMARY:Next-Generation Diagnostics: 10th Annual International Symposium
DESCRIPTION:The 10th International Wyss Institute Symposium will focus on Next-Generation Diagnostics; convening the Institute’s vast network of collaborators\, students\, researchers\, faculty and clinicians alongside industrial researchers\, and members of academic institutions and foundations leading the development of diagnostics technology. This year’s Symposium will highlight the latest developments of this emerging field and address the need for more accurate\, rapid\, and lower cost diagnostic technologies to meet clinical challenges in hospitals\, in physician’s offices\, at home\, and at the point-of-care in both the developed and developing world. Presentations will focus on translation and accelerating the development and application of diagnostic technology toward commercial and clinical application.
URL:https://scienceinboston.com/event/next-generation-diagnostics-10th-annual-international-symposium/
LOCATION:Joseph B. Martin Conference Center\, 77 Avenue Louis Pasteur\, Boston\, MA\, 02115\, United States
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20190919T120000
DTEND;TZID=America/New_York:20190919T160000
DTSTAMP:20190903T191044Z
CREATED:20190903T191044Z
LAST-MODIFIED:20190903T191044Z
UID:27325-1568894400-1568908800@scienceinboston.com
SUMMARY:Fall Career Fair
DESCRIPTION:The WPI Fall Career Fair will be held on September 19\, 2019\, 12pm-4pm and is open to students and alumni of all degrees and disciplines and is ideal for employers looking to fill full-time\, internship\, and co-op positions.
URL:https://scienceinboston.com/event/fall-career-fair-2/
LOCATION:WPI – Sports & Rec Center\, 100 Institute Rd\, Worcester\, MA\, 01609\, United States
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20190919T120000
DTEND;TZID=America/New_York:20190919T160000
DTSTAMP:20190903T191044Z
CREATED:20190903T191044Z
LAST-MODIFIED:20190903T191044Z
UID:6373-1568894400-1568908800@scienceinboston.com
SUMMARY:Fall Career Fair
DESCRIPTION:The WPI Fall Career Fair will be held on September 19\, 2019\, 12pm-4pm and is open to students and alumni of all degrees and disciplines and is ideal for employers looking to fill full-time\, internship\, and co-op positions.
URL:https://scienceinboston.com/event/fall-career-fair/
LOCATION:WPI – Sports & Rec Center\, 100 Institute Rd\, Worcester\, MA\, 01609\, United States
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20190919T083000
DTEND;TZID=America/New_York:20190919T183000
DTSTAMP:20190816T143852Z
CREATED:20190816T143852Z
LAST-MODIFIED:20190816T143852Z
UID:27318-1568881800-1568917800@scienceinboston.com
SUMMARY:Third Annual "Chemical Biology in The HUB" Symposium
DESCRIPTION:This third-in-a-series of scientific talks will focus on cutting edge research in Chemical Biology from both academic and industry labs in the areas of translational chemical biology\, machine learning\, novel target identification and validation\, chemical imaging\, as well as new chemical modalities. \nThis day-long symposium will be followed by a reception with appetizers and refreshments for the symposium speakers and attendees. \nWe wish to thank all of the sponsors and volunteers from industry who are making this possible. Our sponsors include\, in alphabetical order\, The American Chemical Society\, ACS Chemical Biology\, ACS Central Science\, Arrakis Therapeutics\, AstraZeneca\, Biogen\, C4 Therapeutics\, Celgene\, Jnana Therapeutics\, Millipore Sigma\, New England BioLabs\, Northeastern Section of the ACS\, Novartis\, Pfizer\, Sanofi\, Vertex. Our organizers are pleased to continue this fall tradition this year and in the coming years; please be in contact with us (below) if you are interested in participating in future symposia through volunteering\, through sponsorship\, or other means. \nRegistration is required and a ticket will be necessary for admission to the symposium and the networking reception. There are several parking lots located in the area close to Merck. \nRegistration or other questions? Please contact: Andrew Scholte\, Chair of NESACS\, ascholte@gmail.com\n \n\nSchedule of Events (Stay Tuned for Detailed Schedule)\n \n8:30 – 9:00 AM Registration and Breakfast\n \n9:00 AM – 12:20 PM Program \n12:20 PM – 1:30 PM Lunch and Poster Session\n \n1:30 PM – 5:00 PM Program\n \n5:00 PM – 6:30 PM Reception and Poster Session \n\nQuestions? Please contact: Andrew Scholte\, ascholte@gmail.com. \nTHE PUBLIC IS INVITED – RESERVATIONS ARE REQUIRED \n\nFAQs \nWhat are my transport/parking options getting to the event? \nMerck Research Laboratories is located in the Longwood Medical Area and is walking distance from the D-line (Fenway Stop) and E-line (Museum of Fine Arts) of the Green Line. There are also numerous parking garages in the area.  \nPlease contact the organizers regarding carpooling and other options. \nFor driving directions from where you will begin your trip\, enter “33 Avenue Louis Pasteur\, Boston\, MA 02115\,” \nWhere can I contact the organizer with any questions? \nWith any questions whatsoever\, please contact Andrew Scholte\, ascholte@gmail.com \nIs my registration/ticket transferrable? \nYes\, please contact Andrew Scholte before September 12\, 2019.
URL:https://scienceinboston.com/event/third-annual-chemical-biology-in-the-hub-symposium-2/
LOCATION:Merck Research Laboratories\, 33 Avenue Louis Pasteur\, Boston\, MA\, 02115\, United States
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20190919T083000
DTEND;TZID=America/New_York:20190919T183000
DTSTAMP:20190816T143852Z
CREATED:20190816T143852Z
LAST-MODIFIED:20190816T143852Z
UID:6215-1568881800-1568917800@scienceinboston.com
SUMMARY:Third Annual "Chemical Biology in The HUB" Symposium
DESCRIPTION:This third-in-a-series of scientific talks will focus on cutting edge research in Chemical Biology from both academic and industry labs in the areas of translational chemical biology\, machine learning\, novel target identification and validation\, chemical imaging\, as well as new chemical modalities. \nThis day-long symposium will be followed by a reception with appetizers and refreshments for the symposium speakers and attendees. \nWe wish to thank all of the sponsors and volunteers from industry who are making this possible. Our sponsors include\, in alphabetical order\, The American Chemical Society\, ACS Chemical Biology\, ACS Central Science\, Arrakis Therapeutics\, AstraZeneca\, Biogen\, C4 Therapeutics\, Celgene\, Jnana Therapeutics\, Millipore Sigma\, New England BioLabs\, Northeastern Section of the ACS\, Novartis\, Pfizer\, Sanofi\, Vertex. Our organizers are pleased to continue this fall tradition this year and in the coming years; please be in contact with us (below) if you are interested in participating in future symposia through volunteering\, through sponsorship\, or other means. \nRegistration is required and a ticket will be necessary for admission to the symposium and the networking reception. There are several parking lots located in the area close to Merck. \nRegistration or other questions? Please contact: Andrew Scholte\, Chair of NESACS\, ascholte@gmail.com\n \n\nSchedule of Events (Stay Tuned for Detailed Schedule)\n \n8:30 – 9:00 AM Registration and Breakfast\n \n9:00 AM – 12:20 PM Program \n12:20 PM – 1:30 PM Lunch and Poster Session\n \n1:30 PM – 5:00 PM Program\n \n5:00 PM – 6:30 PM Reception and Poster Session \n\nQuestions? Please contact: Andrew Scholte\, ascholte@gmail.com. \nTHE PUBLIC IS INVITED – RESERVATIONS ARE REQUIRED \n\nFAQs \nWhat are my transport/parking options getting to the event? \nMerck Research Laboratories is located in the Longwood Medical Area and is walking distance from the D-line (Fenway Stop) and E-line (Museum of Fine Arts) of the Green Line. There are also numerous parking garages in the area.  \nPlease contact the organizers regarding carpooling and other options. \nFor driving directions from where you will begin your trip\, enter “33 Avenue Louis Pasteur\, Boston\, MA 02115\,” \nWhere can I contact the organizer with any questions? \nWith any questions whatsoever\, please contact Andrew Scholte\, ascholte@gmail.com \nIs my registration/ticket transferrable? \nYes\, please contact Andrew Scholte before September 12\, 2019.
URL:https://scienceinboston.com/event/third-annual-chemical-biology-in-the-hub-symposium/
LOCATION:Merck Research Laboratories\, 33 Avenue Louis Pasteur\, Boston\, MA\, 02115\, United States
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20190917T100000
DTEND;TZID=America/New_York:20190917T150000
DTSTAMP:20190909T144114Z
CREATED:20190909T144114Z
LAST-MODIFIED:20190909T144114Z
UID:27329-1568714400-1568732400@scienceinboston.com
SUMMARY:Mass Cytometry Day
DESCRIPTION:You are invited to Mass Cytometry Day in Boston. Let’s talk about why #heavymetalsrock\n\n\n\n\n\n\nAbout this Event\n\n\nSeminar Talks—Five speakers will share insights\, research\, and results. \nLuncheon—Mingle with other researchers from the surrounding area. \nStep-Right-Up Q&A Table—Discuss your current projects and future ideas with an application scientist. Brand new to Mass Cytometry or Imaging Mass Cytometry? This is the perfect place to start. \nProgram\nContinental Breakfast \ncranberry scones\, miniature banana muffins\, lemon blueberry tea bread \nbottled water\, regular and decaf Starbucks coffee\, assorted Tazo tea \nExecutive Welcome:\nJonathan Day\, VP Commercial Operations\, Fluidigm Corporation \nSpeaker 1: Cynthia Guidos\, PhD\nSenior Scientist\, Developmental and Stem Cell Biology Program\, Hospital for Sick Children Research Institute in Toronto\, ON\, Canada; Professor of Immunology\, Faculty of Medicine\, University of Toronto \n“High Dimensional Characterization of Immune Cells in Normal and Diseased Micro-environments “ \nAbstract : Dissecting disease-driving immune responses presents a major analytical challenge because they are generally mediated by concomitant effects of diverse immune cell lineages\, which are highly dynamic and heterogeneous at both the individual and the population levels. Thus\, highly dimensional single cell and systems-wide approaches are needed to comprehensively characterize the immune cells in health and disease. Helios mass cytometers can measure expression of up to 48 different markers per cell\, making CyTOF the leading technology for discovering biomarkers of immune-mediated diseases. In her presentation\, Dr. Guidos will discuss how she is using mass cytometry to deeply characterize complex cellular immune networks that underlie anti-cancer immune responses and autoimmune diseases. She will describe how her group uses clustering\, machine learning and dimensionality reduction algorithms to automatically identify and visualize differences in subset distribution and functional states across samples in an unbiased fashion. Finally\, Dr. Guidos will overview her use of Fluidigm’s Hyperion multi-plexed imaging mass cytometry platform to enable deep characterization of immune cells within normal and diseased tissue microenvironments. \nSpeaker 2: Emily Thrash\, PhD\nScientist II \, Center for Immuno-Oncology – Immune Assessment Laboratory\, Dana-Farber Cancer Institute \n“Application of high-throughput mass cytometry to phenotype adaptive and innate immune subsets for clinical trials” \nBiomarker discovery in clinical research is currently limited by the inherent complexity of cancer and immune responses in patients\, as well as a lack of validated multi-parameter immuno-phenotyping methodology for large-scale trials. With more measurable parameters than traditional flow cytometry\, mass cytometry (CyTOF) is poised to identify outcome-associated cellular signatures\, follow disease progression and predict therapeutic responses. However\, in a clinical setting\, with large sample numbers collected at different timepoints\, reduction of technical variability is critical. Using healthy donor PBMCs\, we present the design and validation of two CyTOF panels focused on adaptive or innate immune response. Reference sample spike-in decreases batch effects between experiments and we demonstrate high-throughput sample number capabilities. Here we present our workflow and development for robustly immune-phenotyping clinical samples with CyTOF. \nSpeaker 3: Andrew Larry Frelinger\, PhD\nAssistant Professor of Pediatrics\, Harvard Medical School\, Associate Director\, Center for Platelet Research Studies\,Research Associate in Medicine\, Division of Hematology/Oncology\, Dana-Farber/Boston Children’s Cancer and Blood Disorders Center Boston Children’s Hospital/Dana-Farber Cancer Institute \nLunch\nTraditional Sandwich Buffet \nassorted traditional sandwiches: roasted turkey\, roast beef\, smoked ham\, tuna salad\, chicken salad\, tomato\, basil\, mozzarella \nFLIK chips\, hand fruit \nhouse baked FLIK signature chocolate chip cookies \nbottled water\, soda \nSpeaker 4: Douglas Linn\, PhD\nAssociate Principal Scientist\, Merck & Co.\, Inc. \n“Imaging mass cytometry (IMC) as a powerful tool for immunophenotyping human and mouse tissues” \nAbstract: The recent advent of imaging mass cytometry (IMC) applies the technologies of CyTOF to tissue imaging\, building upon key weaknesses of flow cytometry and multiplex immunohistochemistry to establish a powerful tool for examining cellular interactions within complex microenvironments like tumors. We set out to establish and validate IMC capabilities within MRL Boston by analyzing tumors and lymphoid tissue stained with panels of human or mouse markers. Tissue processing and staining protocols were optimized to achieve simultaneous staining of dozens of immune markers\, thus identifying major lymphocyte and myeloid subsets. Unsupervised clustering algorithms allowed examination of expression at population levels or single cell resolution. Together these efforts have validated the use of IMC to profile tumor and lymphoid tissues using large panels of immune markers. The highly multiplexed results that can be obtained will serve an important complementary role in immunophenotyping to explore biology and understand mechanism of action of cancer immunotherapies. \nSpeaker 5: Nikhil Singh\, MD\, PhD\nInstructor\, Section of Nephrology\, Department of Internal Medicinel\, Cantley Lab\, Yale University \n“Highly multiplexed\, spatially preserved analysis of human kidney injury with Imaging Mass Cytometry” \nAbstract: The lack of therapies for acute tubular injury (ATI) derives largely from our incomplete understanding of the biology of the injured human kidney. Although renal biopsy is commonly used in the diagnosis of acute kidney injury\, the small amount of tissue obtained has previously limited the ability to use patient samples for discovery purposes. Imaging mass cytometry (IMC) is a novel technology which permits concurrent analysis of >40 markers on a formalin-fixed tissue section\, ideal for scarce and archival samples. We have developed a highly reproducible methodology for IMC-based interrogation of the human kidney coupled to a machine-learning analysis pipeline. We have utilized this technique to perform comparative\, quantitative\, spatially preserved expression analysis of healthy and injured human tissue. With our combined imaging-analysis approach we have created a reference atlas for the adult human kidney\, defining selected intrinsic and immune cell proportions and their spatial organization in 16 histopathologically normal samples. In injured kidneys with interstitial infiltrate\, we have quantified both expected and novel changes to cellular proportions and tissue architecture. For a cohort of patients who underwent renal biopsy at two affiliated hospitals from 2011-2018 and whose biopsies showed ATI\, we are adjudicating mechanism of injury by chart review and are interrogating banked tissue by IMC to identify immune drivers and cellular responses to injury\, create a quantitative atlas of human ATI\, and elucidate potential targets for therapeutic intervention. We hypothesize that unsupervised clustering of IMC data can be used to develop pathologic signatures corresponding to injury etiology and clinical outcome in ATI.
URL:https://scienceinboston.com/event/mass-cytometry-day-2/
LOCATION:Merck Research Laboratories\, 33 Avenue Louis Pasteur\, Boston\, MA\, 02115\, United States
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20190917T100000
DTEND;TZID=America/New_York:20190917T150000
DTSTAMP:20190909T144114Z
CREATED:20190909T144114Z
LAST-MODIFIED:20190909T144114Z
UID:6429-1568714400-1568732400@scienceinboston.com
SUMMARY:Mass Cytometry Day
DESCRIPTION:You are invited to Mass Cytometry Day in Boston. Let’s talk about why #heavymetalsrock\n\n\n\n\n\n\nAbout this Event\n\n\nSeminar Talks—Five speakers will share insights\, research\, and results. \nLuncheon—Mingle with other researchers from the surrounding area. \nStep-Right-Up Q&A Table—Discuss your current projects and future ideas with an application scientist. Brand new to Mass Cytometry or Imaging Mass Cytometry? This is the perfect place to start. \nProgram\nContinental Breakfast \ncranberry scones\, miniature banana muffins\, lemon blueberry tea bread \nbottled water\, regular and decaf Starbucks coffee\, assorted Tazo tea \nExecutive Welcome:\nJonathan Day\, VP Commercial Operations\, Fluidigm Corporation \nSpeaker 1: Cynthia Guidos\, PhD\nSenior Scientist\, Developmental and Stem Cell Biology Program\, Hospital for Sick Children Research Institute in Toronto\, ON\, Canada; Professor of Immunology\, Faculty of Medicine\, University of Toronto \n“High Dimensional Characterization of Immune Cells in Normal and Diseased Micro-environments “ \nAbstract : Dissecting disease-driving immune responses presents a major analytical challenge because they are generally mediated by concomitant effects of diverse immune cell lineages\, which are highly dynamic and heterogeneous at both the individual and the population levels. Thus\, highly dimensional single cell and systems-wide approaches are needed to comprehensively characterize the immune cells in health and disease. Helios mass cytometers can measure expression of up to 48 different markers per cell\, making CyTOF the leading technology for discovering biomarkers of immune-mediated diseases. In her presentation\, Dr. Guidos will discuss how she is using mass cytometry to deeply characterize complex cellular immune networks that underlie anti-cancer immune responses and autoimmune diseases. She will describe how her group uses clustering\, machine learning and dimensionality reduction algorithms to automatically identify and visualize differences in subset distribution and functional states across samples in an unbiased fashion. Finally\, Dr. Guidos will overview her use of Fluidigm’s Hyperion multi-plexed imaging mass cytometry platform to enable deep characterization of immune cells within normal and diseased tissue microenvironments. \nSpeaker 2: Emily Thrash\, PhD\nScientist II \, Center for Immuno-Oncology – Immune Assessment Laboratory\, Dana-Farber Cancer Institute \n“Application of high-throughput mass cytometry to phenotype adaptive and innate immune subsets for clinical trials” \nBiomarker discovery in clinical research is currently limited by the inherent complexity of cancer and immune responses in patients\, as well as a lack of validated multi-parameter immuno-phenotyping methodology for large-scale trials. With more measurable parameters than traditional flow cytometry\, mass cytometry (CyTOF) is poised to identify outcome-associated cellular signatures\, follow disease progression and predict therapeutic responses. However\, in a clinical setting\, with large sample numbers collected at different timepoints\, reduction of technical variability is critical. Using healthy donor PBMCs\, we present the design and validation of two CyTOF panels focused on adaptive or innate immune response. Reference sample spike-in decreases batch effects between experiments and we demonstrate high-throughput sample number capabilities. Here we present our workflow and development for robustly immune-phenotyping clinical samples with CyTOF. \nSpeaker 3: Andrew Larry Frelinger\, PhD\nAssistant Professor of Pediatrics\, Harvard Medical School\, Associate Director\, Center for Platelet Research Studies\,Research Associate in Medicine\, Division of Hematology/Oncology\, Dana-Farber/Boston Children’s Cancer and Blood Disorders Center Boston Children’s Hospital/Dana-Farber Cancer Institute \nLunch\nTraditional Sandwich Buffet \nassorted traditional sandwiches: roasted turkey\, roast beef\, smoked ham\, tuna salad\, chicken salad\, tomato\, basil\, mozzarella \nFLIK chips\, hand fruit \nhouse baked FLIK signature chocolate chip cookies \nbottled water\, soda \nSpeaker 4: Douglas Linn\, PhD\nAssociate Principal Scientist\, Merck & Co.\, Inc. \n“Imaging mass cytometry (IMC) as a powerful tool for immunophenotyping human and mouse tissues” \nAbstract: The recent advent of imaging mass cytometry (IMC) applies the technologies of CyTOF to tissue imaging\, building upon key weaknesses of flow cytometry and multiplex immunohistochemistry to establish a powerful tool for examining cellular interactions within complex microenvironments like tumors. We set out to establish and validate IMC capabilities within MRL Boston by analyzing tumors and lymphoid tissue stained with panels of human or mouse markers. Tissue processing and staining protocols were optimized to achieve simultaneous staining of dozens of immune markers\, thus identifying major lymphocyte and myeloid subsets. Unsupervised clustering algorithms allowed examination of expression at population levels or single cell resolution. Together these efforts have validated the use of IMC to profile tumor and lymphoid tissues using large panels of immune markers. The highly multiplexed results that can be obtained will serve an important complementary role in immunophenotyping to explore biology and understand mechanism of action of cancer immunotherapies. \nSpeaker 5: Nikhil Singh\, MD\, PhD\nInstructor\, Section of Nephrology\, Department of Internal Medicinel\, Cantley Lab\, Yale University \n“Highly multiplexed\, spatially preserved analysis of human kidney injury with Imaging Mass Cytometry” \nAbstract: The lack of therapies for acute tubular injury (ATI) derives largely from our incomplete understanding of the biology of the injured human kidney. Although renal biopsy is commonly used in the diagnosis of acute kidney injury\, the small amount of tissue obtained has previously limited the ability to use patient samples for discovery purposes. Imaging mass cytometry (IMC) is a novel technology which permits concurrent analysis of >40 markers on a formalin-fixed tissue section\, ideal for scarce and archival samples. We have developed a highly reproducible methodology for IMC-based interrogation of the human kidney coupled to a machine-learning analysis pipeline. We have utilized this technique to perform comparative\, quantitative\, spatially preserved expression analysis of healthy and injured human tissue. With our combined imaging-analysis approach we have created a reference atlas for the adult human kidney\, defining selected intrinsic and immune cell proportions and their spatial organization in 16 histopathologically normal samples. In injured kidneys with interstitial infiltrate\, we have quantified both expected and novel changes to cellular proportions and tissue architecture. For a cohort of patients who underwent renal biopsy at two affiliated hospitals from 2011-2018 and whose biopsies showed ATI\, we are adjudicating mechanism of injury by chart review and are interrogating banked tissue by IMC to identify immune drivers and cellular responses to injury\, create a quantitative atlas of human ATI\, and elucidate potential targets for therapeutic intervention. We hypothesize that unsupervised clustering of IMC data can be used to develop pathologic signatures corresponding to injury etiology and clinical outcome in ATI.
URL:https://scienceinboston.com/event/mass-cytometry-day/
LOCATION:Merck Research Laboratories\, 33 Avenue Louis Pasteur\, Boston\, MA\, 02115\, United States
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20190913T173000
DTEND;TZID=America/New_York:20190913T193000
DTSTAMP:20190905T173049Z
CREATED:20190905T173049Z
LAST-MODIFIED:20190905T173049Z
UID:27326-1568395800-1568403000@scienceinboston.com
SUMMARY:Science in Boston Meet and Greet
DESCRIPTION:Join us on Friday\, September 13th at Meadhall to wind down from your work week with some cold ones\, cool science\, and the opportunity to win a sweet prize! \nTime: 5:30 – 7:30 PM \nVenue: Meadhall\, 4 Cambridge Center\, 90 Broadway\, Cambridge\, MA 021424 Cambridge Center\, 90 Broadway\, Cambridge\, MA 02142
URL:https://scienceinboston.com/event/science-in-boston-meet-and-greet-2/
LOCATION:Meadhall\, 4 Cambridge Center\, 90 Broadway\, Cambridge\, MA\, 02142\, United States
ATTACH;FMTTYPE=image/jpeg:https://scienceinboston.com/wp-content/uploads/sites/6/2019/09/SO356CXN-Science-in-Boston-Meet-Greet-1100x628.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20190913T173000
DTEND;TZID=America/New_York:20190913T193000
DTSTAMP:20190905T173049Z
CREATED:20190905T173049Z
LAST-MODIFIED:20190905T173049Z
UID:6392-1568395800-1568403000@scienceinboston.com
SUMMARY:Science in Boston Meet and Greet
DESCRIPTION:Join us on Friday\, September 13th at Meadhall to wind down from your work week with some cold ones\, cool science\, and the opportunity to win a sweet prize! \nTime: 5:30 – 7:30 PM \nVenue: Meadhall\, 4 Cambridge Center\, 90 Broadway\, Cambridge\, MA 021424 Cambridge Center\, 90 Broadway\, Cambridge\, MA 02142
URL:https://scienceinboston.com/event/science-in-boston-meet-and-greet/
LOCATION:Meadhall\, 4 Cambridge Center\, 90 Broadway\, Cambridge\, MA\, 02142\, United States
ATTACH;FMTTYPE=image/jpeg:https://scienceinboston.com/wp-content/uploads/sites/6/2019/09/SO356CXN-Science-in-Boston-Meet-Greet-1100x628.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20190912T143000
DTEND;TZID=America/New_York:20190912T173000
DTSTAMP:20190816T151708Z
CREATED:20190816T151708Z
LAST-MODIFIED:20190816T151708Z
UID:6223-1568298600-1568309400@scienceinboston.com
SUMMARY:FRAXA Biotech Games
DESCRIPTION:FRAXA Biotech Games™ raise money for research while giving members of the Boston biotech community the opportunity to meet each other and network in a friendly setting to share camaraderie\, experiences and expertise which then strengthens the Boston scientific ecosystem. \nProceeds of the event support FRAXA Research Foundation\, which funds Fragile X research in Boston area labs\, including the Mark Bear Lab at MIT’s Picower Institute and the Jeannie Lee Lab at Harvard/Mass General. FRAXA’s mission is to find effective treatments and ultimately a cure for Fragile X\, the most common inherited cause of autism and learning disabilities worldwide. \nRegistration begins at 2:30 pm. The Games start at 3:30 pm and will conclude at 5:30 pm\, immediately followed by a networking reception BBQ with food and Cash bar on The Common  from 5:30 -7:30 pm. Awards will be presented\, including awarding the Cup to the top company\, whose team achieves the highest overall score in the competition. There will be several consolation prizes as well. \nDon’t miss out! Register your team today – team slots will be filled on a first come first served basis! A team consists of 2-4 players. For more information please contact Dave Bjork at dbjorl@fraxa.org or sbeaulieu@connerstrong.com
URL:https://scienceinboston.com/event/fraxa-biotech-games/
LOCATION:The Common at Cambridge Crossing\, Cambridge\, MA\, United States
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20190912T143000
DTEND;TZID=America/New_York:20190912T173000
DTSTAMP:20190816T151708Z
CREATED:20190816T151708Z
LAST-MODIFIED:20190816T151708Z
UID:27321-1568298600-1568309400@scienceinboston.com
SUMMARY:FRAXA Biotech Games
DESCRIPTION:FRAXA Biotech Games™ raise money for research while giving members of the Boston biotech community the opportunity to meet each other and network in a friendly setting to share camaraderie\, experiences and expertise which then strengthens the Boston scientific ecosystem. \nProceeds of the event support FRAXA Research Foundation\, which funds Fragile X research in Boston area labs\, including the Mark Bear Lab at MIT’s Picower Institute and the Jeannie Lee Lab at Harvard/Mass General. FRAXA’s mission is to find effective treatments and ultimately a cure for Fragile X\, the most common inherited cause of autism and learning disabilities worldwide. \nRegistration begins at 2:30 pm. The Games start at 3:30 pm and will conclude at 5:30 pm\, immediately followed by a networking reception BBQ with food and Cash bar on The Common  from 5:30 -7:30 pm. Awards will be presented\, including awarding the Cup to the top company\, whose team achieves the highest overall score in the competition. There will be several consolation prizes as well. \nDon’t miss out! Register your team today – team slots will be filled on a first come first served basis! A team consists of 2-4 players. For more information please contact Dave Bjork at dbjorl@fraxa.org or sbeaulieu@connerstrong.com
URL:https://scienceinboston.com/event/fraxa-biotech-games-2/
LOCATION:The Common at Cambridge Crossing\, Cambridge\, MA\, United States
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20190911T143000
DTEND;TZID=America/New_York:20190911T174500
DTSTAMP:20190816T145733Z
CREATED:20190816T145733Z
LAST-MODIFIED:20190816T145733Z
UID:27320-1568212200-1568223900@scienceinboston.com
SUMMARY:Career Pathways for Researchers Interested in Government and Regulatory Agencies
DESCRIPTION:This panel session offers attendees an overview of the various career options available within government and regulatory agencies and provides an opportunity for participants to present questions to expert panelists. \nKeynote Speaker: \nJodi Black\, PhD\, Deputy Director of the NIH Office of Extramural Research\, NIH \nPanel Discussion and Q&A Session: \nMonica Bharel\, MD\, MPH\, Commissioner of the Massachusetts Department of Public Health \nMary Woolley\, President of Research!America\, Research!America \n  \nRegistration closes September 11. \nQuestions? Please email education@catalyst.harvard.edu.
URL:https://scienceinboston.com/event/career-pathways-for-researchers-interested-in-government-and-regulatory-agencies-2/
LOCATION:Harvard Medical School\, 25 Shattuck St\, Boston\, MA\, United States
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20190911T143000
DTEND;TZID=America/New_York:20190911T174500
DTSTAMP:20190816T145733Z
CREATED:20190816T145733Z
LAST-MODIFIED:20190816T145733Z
UID:6221-1568212200-1568223900@scienceinboston.com
SUMMARY:Career Pathways for Researchers Interested in Government and Regulatory Agencies
DESCRIPTION:This panel session offers attendees an overview of the various career options available within government and regulatory agencies and provides an opportunity for participants to present questions to expert panelists. \nKeynote Speaker: \nJodi Black\, PhD\, Deputy Director of the NIH Office of Extramural Research\, NIH \nPanel Discussion and Q&A Session: \nMonica Bharel\, MD\, MPH\, Commissioner of the Massachusetts Department of Public Health \nMary Woolley\, President of Research!America\, Research!America \n  \nRegistration closes September 11. \nQuestions? Please email education@catalyst.harvard.edu.
URL:https://scienceinboston.com/event/career-pathways-for-researchers-interested-in-government-and-regulatory-agencies/
LOCATION:Harvard Medical School\, 25 Shattuck St\, Boston\, MA\, United States
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20190911T080000
DTEND;TZID=America/New_York:20190912T170000
DTSTAMP:20190816T145402Z
CREATED:20190816T145402Z
LAST-MODIFIED:20190816T145402Z
UID:6218-1568188800-1568307600@scienceinboston.com
SUMMARY:NCATS Assay Guidance Workshop for High-Throughput Screening and Lead Discovery
DESCRIPTION:This free two day workshop will cover a broad range of critical concepts underlying assay development and implementation for high throughput screening (HTS) and lead discovery projects. Many of the methodologies successfully implemented in such projects have established a good deal of “tribal knowledge” within the pharmaceutical industry which is not readily found in a classroom or the literature. This tribal knowledge\, developed over decades\, has been transferred into detailed chapters within the Assay Guidance Manual to facilitate reproducible and robust assays that can identify the most promising compounds for the development of molecular probes or clinical candidates. The workshop will provide participants with a broad\, practical perspective on assay development so that they can (1) improve research projects involving drug discovery\, and know where to find further information (2) identify reagents\, methods and instrumentation that are well suited to robust assays and (3) develop robust assays and the required counter and secondary assays for targets of interest.
URL:https://scienceinboston.com/event/ncats-assay-guidance-workshop-for-high-throughput-screening-and-lead-discovery/
LOCATION:Pfizer Kendall Square\, 1 Portland Square\, Cambridge\, MA\, 02139\, United States
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20190911T080000
DTEND;TZID=America/New_York:20190912T170000
DTSTAMP:20190816T145402Z
CREATED:20190816T145402Z
LAST-MODIFIED:20190816T145402Z
UID:27319-1568188800-1568307600@scienceinboston.com
SUMMARY:NCATS Assay Guidance Workshop for High-Throughput Screening and Lead Discovery
DESCRIPTION:This free two day workshop will cover a broad range of critical concepts underlying assay development and implementation for high throughput screening (HTS) and lead discovery projects. Many of the methodologies successfully implemented in such projects have established a good deal of “tribal knowledge” within the pharmaceutical industry which is not readily found in a classroom or the literature. This tribal knowledge\, developed over decades\, has been transferred into detailed chapters within the Assay Guidance Manual to facilitate reproducible and robust assays that can identify the most promising compounds for the development of molecular probes or clinical candidates. The workshop will provide participants with a broad\, practical perspective on assay development so that they can (1) improve research projects involving drug discovery\, and know where to find further information (2) identify reagents\, methods and instrumentation that are well suited to robust assays and (3) develop robust assays and the required counter and secondary assays for targets of interest.
URL:https://scienceinboston.com/event/ncats-assay-guidance-workshop-for-high-throughput-screening-and-lead-discovery-2/
LOCATION:Pfizer Kendall Square\, 1 Portland Square\, Cambridge\, MA\, 02139\, United States
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20190911T080000
DTEND;TZID=America/New_York:20190911T170000
DTSTAMP:20190909T144542Z
CREATED:20190909T144542Z
LAST-MODIFIED:20190909T144542Z
UID:27330-1568188800-1568221200@scienceinboston.com
SUMMARY:Physicochemical Properties Workshop
DESCRIPTION:This workshop will foster discussion around techniques for measuring physicochemical properties and their applications in drug discovery.\n\n\n\n\n\n\nAbout this Event\n\n\nWORKSHOP SCHEDULE \n8:00 am – 9:00 am: Registration and Breakfast \n9:00 am – 9:30 am: Opening Remarks and Introductions \n9:30 am – 10:15 am: Franco Lombardo\, Senior Director of DMPK and Bioanalysis\, Alkermes – Perspectives on the Use of PhysChem in Lead Development \n10:15 am – 10:30 am: Coffee Break \n10:30 am – 11:15 am: Giulia Caron\, Professor in Medicinal Chemistry\, Expert in Molecular Properties\, University of Turin – Beyond Rule of 5 Space \n11:15 am – 12:00 pm: Attendee and Panel Discussion: How are Physicochemical Properties used in the Pharmaceutical Industry? \n12:00 pm – 1:00 pm: Lunch \n1:00 pm – 1:30 pm: Sarah St. John\, Pharma Business Development Manager\, Phenomenex– Use of Chromatographic Support to Highlight Interactions \n1:30 pm – 2:15 pm: Attendee and Panel Discussion: Potential Interest in New Descriptors\, New Techniques\, Need for Additional Tools\, Higher Throughput…? \n2:15 pm – 2:30 pm: Coffee Break \n2:30 pm – 3:00 pm: Gilles Goetz\, Principal Scientist\, Pfizer Inc. – New Techniques such as EPSA \n3:00 pm – 3:30 pm: Simone Sciabola\, Principal Scientist\, Biogen – Use of In Silico Tools\, with Applications on EPSA Model \n3:30 pm – 4:00 pm: Closing Remarks \n4:00 pm – 5:00 pm: Networking time \nQuestions? Please contact: \nKate Favre\, Senior Account Manager\, Analiza \nkate.favre@analiza.com \n(440) 241-4196 \n\n\nPresented by: \n\n\n\nPlease visit our website! www.analiza.com
URL:https://scienceinboston.com/event/physicochemical-properties-workshop-2/
LOCATION:Hilton Garden Inn Boston/Waltham\, 450 Totten Pond Road\, Waltham\, MA\, 02451\, United States
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20190911T080000
DTEND;TZID=America/New_York:20190911T170000
DTSTAMP:20190909T144542Z
CREATED:20190909T144542Z
LAST-MODIFIED:20190909T144542Z
UID:6431-1568188800-1568221200@scienceinboston.com
SUMMARY:Physicochemical Properties Workshop
DESCRIPTION:This workshop will foster discussion around techniques for measuring physicochemical properties and their applications in drug discovery.\n\n\n\n\n\n\nAbout this Event\n\n\nWORKSHOP SCHEDULE \n8:00 am – 9:00 am: Registration and Breakfast \n9:00 am – 9:30 am: Opening Remarks and Introductions \n9:30 am – 10:15 am: Franco Lombardo\, Senior Director of DMPK and Bioanalysis\, Alkermes – Perspectives on the Use of PhysChem in Lead Development \n10:15 am – 10:30 am: Coffee Break \n10:30 am – 11:15 am: Giulia Caron\, Professor in Medicinal Chemistry\, Expert in Molecular Properties\, University of Turin – Beyond Rule of 5 Space \n11:15 am – 12:00 pm: Attendee and Panel Discussion: How are Physicochemical Properties used in the Pharmaceutical Industry? \n12:00 pm – 1:00 pm: Lunch \n1:00 pm – 1:30 pm: Sarah St. John\, Pharma Business Development Manager\, Phenomenex– Use of Chromatographic Support to Highlight Interactions \n1:30 pm – 2:15 pm: Attendee and Panel Discussion: Potential Interest in New Descriptors\, New Techniques\, Need for Additional Tools\, Higher Throughput…? \n2:15 pm – 2:30 pm: Coffee Break \n2:30 pm – 3:00 pm: Gilles Goetz\, Principal Scientist\, Pfizer Inc. – New Techniques such as EPSA \n3:00 pm – 3:30 pm: Simone Sciabola\, Principal Scientist\, Biogen – Use of In Silico Tools\, with Applications on EPSA Model \n3:30 pm – 4:00 pm: Closing Remarks \n4:00 pm – 5:00 pm: Networking time \nQuestions? Please contact: \nKate Favre\, Senior Account Manager\, Analiza \nkate.favre@analiza.com \n(440) 241-4196 \n\n\nPresented by: \n\n\n\nPlease visit our website! www.analiza.com
URL:https://scienceinboston.com/event/physicochemical-properties-workshop/
LOCATION:Hilton Garden Inn Boston/Waltham\, 450 Totten Pond Road\, Waltham\, MA\, 02451\, United States
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20190910T114500
DTEND;TZID=America/New_York:20190910T130000
DTSTAMP:20190821T151231Z
CREATED:20190821T151231Z
LAST-MODIFIED:20190821T151231Z
UID:27324-1568115900-1568120400@scienceinboston.com
SUMMARY:From Bedside to Bench—Streamlined Workflow for Disease-modeling Using Patient-specific iPSC-derived Neurons.
DESCRIPTION:Join us and fellow scientists for lunch and a seminar on streamlining your workflow for disease modeling using patient-specific iPSC-derived neurons. The seminar will be held at STEMCELL Technologies’ office in Cambridge\, MA and feature the Assistant Director of Human Neuron Differentiation Services at Boston Children’s Hospital’s Human Neuron Core\, Dr. Ivy Pin-Fang Chen. Complimentary lunch will be provided. \nSpace is limited. RSVP before Sep 3 to reserve your spot! \n\n\n\n\n\n\nIvy Pin-Fang Chen\, PhD\nAssistant Director\, Human Neuron Differentiation Services\nHuman Neuron Core\, Boston Children’s Hospital\n\n\n\n\n\n\n\nFrom Bedside to Bench—Streamlined Workflow for Disease-modeling Using Patient-specific iPSC-derived Neurons.Tuesday\, Sep 10\, 2019 | 11:45 a.m. – 1:00 p.m. \nLocationSTEMCELL Technologies Inc. Cambridge Office\n222 Third Street\, Suite 2323\, Cambridge\, MA
URL:https://scienceinboston.com/event/from-bedside-to-bench-streamlined-workflow-for-disease-modeling-using-patient-specific-ipsc-derived-neurons-2/
LOCATION:STEMCELL Tech\, Suite 2323-222 Third Street\, Cambridge\, MA\, 02142\, United States
ORGANIZER;CN="STEMCELL Technologies":MAILTO:info@stemcell.com
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20190910T114500
DTEND;TZID=America/New_York:20190910T130000
DTSTAMP:20190821T151231Z
CREATED:20190821T151231Z
LAST-MODIFIED:20190821T151231Z
UID:6297-1568115900-1568120400@scienceinboston.com
SUMMARY:From Bedside to Bench—Streamlined Workflow for Disease-modeling Using Patient-specific iPSC-derived Neurons.
DESCRIPTION:Join us and fellow scientists for lunch and a seminar on streamlining your workflow for disease modeling using patient-specific iPSC-derived neurons. The seminar will be held at STEMCELL Technologies’ office in Cambridge\, MA and feature the Assistant Director of Human Neuron Differentiation Services at Boston Children’s Hospital’s Human Neuron Core\, Dr. Ivy Pin-Fang Chen. Complimentary lunch will be provided. \nSpace is limited. RSVP before Sep 3 to reserve your spot! \n\n\n\n\n\n\nIvy Pin-Fang Chen\, PhD\nAssistant Director\, Human Neuron Differentiation Services\nHuman Neuron Core\, Boston Children’s Hospital\n\n\n\n\n\n\n\nFrom Bedside to Bench—Streamlined Workflow for Disease-modeling Using Patient-specific iPSC-derived Neurons.Tuesday\, Sep 10\, 2019 | 11:45 a.m. – 1:00 p.m. \nLocationSTEMCELL Technologies Inc. Cambridge Office\n222 Third Street\, Suite 2323\, Cambridge\, MA
URL:https://scienceinboston.com/event/from-bedside-to-bench-streamlined-workflow-for-disease-modeling-using-patient-specific-ipsc-derived-neurons/
LOCATION:STEMCELL Tech\, Suite 2323-222 Third Street\, Cambridge\, MA\, 02142\, United States
ORGANIZER;CN="STEMCELL Technologies":MAILTO:info@stemcell.com
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20190909T170000
DTEND;TZID=America/New_York:20190909T190000
DTSTAMP:20190909T143453Z
CREATED:20190909T143453Z
LAST-MODIFIED:20190909T143453Z
UID:27327-1568048400-1568055600@scienceinboston.com
SUMMARY:CyTOF Analysis Workshop Series
DESCRIPTION:Invited speakers from Dana-Farber Cancer Institute and Bluebird Bio will talk about panel validation and addressing batch effect.\n\n\n\n\n\n\nAbout this Event\n\n\nSpeaker: Emily Thrash\, PhD\, Scientist II\, Dana-Farber Cancer Institute\nBio: Experienced Cancer Immunologist with a proven history of developing clinical trial correlative studies. Highly skilled in Flow Cytometry and CyTOF\, especially with primary patient samples. Patient-oriented\, results-driven research professional with a Doctorate in Biomedical Sciences\, Immunology from The Ohio State University College of Medicine. \nAbstract: CyTOF is revolutionizing correlative clinical trial studies allowing for deeper immune-phenotyping compared to traditional flow cytometry. Leveraging CyTOF technology\, our group has previously identified biomarkers of response to anti-PD-1 therapy in melanoma patients. Building upon those studies\, we have developed two CyTOF panels 1) Adaptive (CPB-A) and 2) Innate (CPB-I) that identify immune cell subsets and test biomarkers for response and resistance in patients receiving anti-PD-1 therapy. Here we present the validation of these panels\, as well as our method pipeline for CyTOF panel development. \nSpeaker: Brandon Nguyen\, Sr. Associate Scientist I\, Bluebird Bio\nAbstract: Mass Cytometry presents a unique opportunity to look at 40 antigens at once on a single cell basis\, this is particularly useful when trying to phenotypically characterize a cellular drug product. Currently at bluebird bio there are three clinical phase cellular drug products that leverage autologous CD34+ hematopoietic stem cells edited with lentiviral vector. Because hematopoiesis is a very fluid landscape\, we have developed a classification method to divide the CD34+ drug product into lineage specific progenitors and precursors with the help of high dimensional clustering. This characterization data set can then be used for correlative studies within each clinical trial and across multiple clinical trials. However\, in order to ensure data integrity for meaningful comparative studies a reference must be used to track staining consistency of each antibody. This was found to be necessary as batch effects played an important role into the potential skewing of high dimensional analysis. Overall\, longitudinal studies are a challenge due to batch specific staining variation\, however the variation can be minimized by tracking a reference cell bank and strategic optimization.
URL:https://scienceinboston.com/event/cytof-analysis-workshop-series-2/
LOCATION:Bluebird Bio\, 60 Binney Street\, Cambridge\, MA\, 02142\, United States
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20190909T170000
DTEND;TZID=America/New_York:20190909T190000
DTSTAMP:20190909T143544Z
CREATED:20190909T143453Z
LAST-MODIFIED:20190909T143544Z
UID:6424-1568048400-1568055600@scienceinboston.com
SUMMARY:CyTOF Analysis Workshop Series
DESCRIPTION:Invited speakers from Dana-Farber Cancer Institute and Bluebird Bio will talk about panel validation and addressing batch effect.\n\n\n\n\n\n\nAbout this Event\n\n\nSpeaker: Emily Thrash\, PhD\, Scientist II\, Dana-Farber Cancer Institute\nBio: Experienced Cancer Immunologist with a proven history of developing clinical trial correlative studies. Highly skilled in Flow Cytometry and CyTOF\, especially with primary patient samples. Patient-oriented\, results-driven research professional with a Doctorate in Biomedical Sciences\, Immunology from The Ohio State University College of Medicine. \nAbstract: CyTOF is revolutionizing correlative clinical trial studies allowing for deeper immune-phenotyping compared to traditional flow cytometry. Leveraging CyTOF technology\, our group has previously identified biomarkers of response to anti-PD-1 therapy in melanoma patients. Building upon those studies\, we have developed two CyTOF panels 1) Adaptive (CPB-A) and 2) Innate (CPB-I) that identify immune cell subsets and test biomarkers for response and resistance in patients receiving anti-PD-1 therapy. Here we present the validation of these panels\, as well as our method pipeline for CyTOF panel development. \nSpeaker: Brandon Nguyen\, Sr. Associate Scientist I\, Bluebird Bio\nAbstract: Mass Cytometry presents a unique opportunity to look at 40 antigens at once on a single cell basis\, this is particularly useful when trying to phenotypically characterize a cellular drug product. Currently at bluebird bio there are three clinical phase cellular drug products that leverage autologous CD34+ hematopoietic stem cells edited with lentiviral vector. Because hematopoiesis is a very fluid landscape\, we have developed a classification method to divide the CD34+ drug product into lineage specific progenitors and precursors with the help of high dimensional clustering. This characterization data set can then be used for correlative studies within each clinical trial and across multiple clinical trials. However\, in order to ensure data integrity for meaningful comparative studies a reference must be used to track staining consistency of each antibody. This was found to be necessary as batch effects played an important role into the potential skewing of high dimensional analysis. Overall\, longitudinal studies are a challenge due to batch specific staining variation\, however the variation can be minimized by tracking a reference cell bank and strategic optimization.
URL:https://scienceinboston.com/event/cytof-analysis-workshop-series/
LOCATION:Bluebird Bio\, 60 Binney Street\, Cambridge\, MA\, 02142\, United States
END:VEVENT
END:VCALENDAR