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SUMMARY:Ensuring Equitable Access To New Gene Therapies
DESCRIPTION:While recent clinical trials of innovative\, new gene therapies show incredible promise for patients who have faced a lifetime of unmet medical needs\, the biggest challenge for these therapies is yet to come – ensuring equitable access. \nA critical moment for this issue could be the development of new therapies for sickle cell disease\, which affects approximately one in 365 Black Americans. What can the life sciences do to ensure that all patients have access to what could be life-changing medicines? \nIn this month’s Make Shift Happen\, panelists from the gene therapy sector and patient advocacy space will discuss: \n\nThe current state of ED&I in therapeutic development\nTaking a patient-centric approach to developing new gene therapies\nChallenges and opportunities for improving therapeutic accessibility
URL:https://scienceinboston.com/event/ensuring-equitable-access-to-new-gene-therapies/
LOCATION:Online
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LAST-MODIFIED:20210315T154739Z
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SUMMARY:Ensuring Equitable Access To New Gene Therapies
DESCRIPTION:While recent clinical trials of innovative\, new gene therapies show incredible promise for patients who have faced a lifetime of unmet medical needs\, the biggest challenge for these therapies is yet to come – ensuring equitable access. \nA critical moment for this issue could be the development of new therapies for sickle cell disease\, which affects approximately one in 365 Black Americans. What can the life sciences do to ensure that all patients have access to what could be life-changing medicines? \nIn this month’s Make Shift Happen\, panelists from the gene therapy sector and patient advocacy space will discuss: \n\nThe current state of ED&I in therapeutic development\nTaking a patient-centric approach to developing new gene therapies\nChallenges and opportunities for improving therapeutic accessibility
URL:https://scienceinboston.com/event/ensuring-equitable-access-to-new-gene-therapies-2/
LOCATION:Online
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DTSTAMP:20260619T043553
CREATED:20210325T165855Z
LAST-MODIFIED:20210325T165912Z
UID:13563-1617638400-1617642000@scienceinboston.com
SUMMARY:Joshua Sanes | Cell Types as Building Blocks of Neural Circuits
DESCRIPTION:Join us for the 2021 Edward M. Scolnick Prize in Neuroscience Lecture \nCell Types as Building Blocks of Neural Circuits \nJoshua Sanes\, Harvard University \nAbstract: Classification of neurons was a major preoccupation of Cajal\, but later came to be viewed as a fairly boring enterprise. Over the past few decades\, however\, inability to define neuronal types emerged as a major bottleneck in analysis of neural circuits and brain disorders. The introduction of high throughput single cell RNAseq in 2015 provided a new way to approach this problem. I will describe its use to generate an atlas of 130 cell types from mouse retina\, a particularly accessible part of the brain\, and then show how the atlas can be used to probe development\, function and dysfunction in new ways: (1) Profiling embryonic retinal ganglion cells (RGCs) to learn how they diversify into ~45 types. (2) Analyzing RGC types following damage to demonstrate dramatic differences in their resilience to injury and identify genes that contribute to resilience. (3) Generating primate retinal atlases and using them to assess expression of genes implicated in blinding diseases. (4) Probing the evolution of cell types by profiling cells from many vertebrate species. \nRegister in advance for this webinar: https://mit.zoom.us/webinar/register/WN_pwTd05G6RlWhwXgMMFhv1w
URL:https://scienceinboston.com/event/joshua-sanes-cell-types-as-building-blocks-of-neural-circuits/
LOCATION:Online
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LAST-MODIFIED:20210325T165855Z
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SUMMARY:Joshua Sanes | Cell Types as Building Blocks of Neural Circuits
DESCRIPTION:Join us for the 2021 Edward M. Scolnick Prize in Neuroscience Lecture \nCell Types as Building Blocks of Neural Circuits \nJoshua Sanes\, Harvard University \nAbstract: Classification of neurons was a major preoccupation of Cajal\, but later came to be viewed as a fairly boring enterprise. Over the past few decades\, however\, inability to define neuronal types emerged as a major bottleneck in analysis of neural circuits and brain disorders. The introduction of high throughput single cell RNAseq in 2015 provided a new way to approach this problem. I will describe its use to generate an atlas of 130 cell types from mouse retina\, a particularly accessible part of the brain\, and then show how the atlas can be used to probe development\, function and dysfunction in new ways: (1) Profiling embryonic retinal ganglion cells (RGCs) to learn how they diversify into ~45 types. (2) Analyzing RGC types following damage to demonstrate dramatic differences in their resilience to injury and identify genes that contribute to resilience. (3) Generating primate retinal atlases and using them to assess expression of genes implicated in blinding diseases. (4) Probing the evolution of cell types by profiling cells from many vertebrate species. \nRegister in advance for this webinar: https://mit.zoom.us/webinar/register/WN_pwTd05G6RlWhwXgMMFhv1w
URL:https://scienceinboston.com/event/joshua-sanes-cell-types-as-building-blocks-of-neural-circuits-2/
LOCATION:Online
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