Publications of the Week Epigenomic Regulation of Stemness Contributes to the Low Immunogenicity of the Most Mutated Human Cancer Oka, T., et al. | April 28, 2025 Despite harboring the highest tumor mutational burden of all cancers, basal cell carcinoma (BCC) has…karnottApril 28, 2025 Read More
Publications of the Week Rules of Engagement for Condensins and Cohesins Guide Mitotic Chromosome Formation Samejima, K., et al. | April 23, 2025 Structural maintenance of chromosomes (SMC) protein complexes, which include cohesin and condensin, play crucial roles…karnottApril 23, 2025 Read More
Publications of the Week Transcription Factor Networks Disproportionately Enrich for Heritability of Blood Cell Phenotypes Martin-Rufino, J., et al. | April 21, 2025 This week, we profile a recent publication in Science by Dr. Vijay Sankaran’s lab (pictured,…karnottApril 21, 2025 Read More
Publications of the Week Immune Checkpoint TIM-3 Regulates Microglia and Alzheimer’s Disease Kimura, K., et al. | April 17, 2025 Microglia are the resident immune cells in the brain and have pivotal roles in neurodevelopment…karnottApril 17, 2025 Read More
Publications of the Week Lysine Vitcylation Is a Vitamin C-Derived Protein Modification That Enhances STAT1-Mediated Immune Response He, X., et al. | April 15, 2025 Vitamin C (vitC) is essential for health and shows promise in treating diseases like cancer,…karnottApril 15, 2025 Read More
Publications of the Week Molecular Basis for Shifted Receptor Recognition by an Encephalitic Arbovirus Fan, X., et al. | April 11, 2025 Western equine encephalitis virus (WEEV) is an arbovirus that historically caused large outbreaks of encephalitis…karnottApril 11, 2025 Read More
Publications of the Week Identification of a Molecular Resistor That Controls UCP1-Independent Ca2+ Cycling Thermogenesis in Adipose Tissue Auger, C., et al. | April 8, 2025 Adipose tissue thermogenesis contributes to energy balance via mitochondrial uncoupling protein 1 (UCP1) and UCP1-independent…karnottApril 8, 2025 Read More
Publications of the Week Functional Diversification of Dietary Plant Small Molecules by the Gut Microbiome Kuziel, G., et al. | April 4, 2025 Plants are composed of diverse secondary metabolites (PSMs), which are widely associated with human health.…karnottApril 4, 2025 Read More
Publications of the Week Enteric Neuronal Piezo1 Maintains Mechanical and Immunological Homeostasis by Sensing Force Xie, Z., et al. | April 2, 2025 The gastrointestinal (GI) tract experiences a myriad of mechanical forces while orchestrating digestion and barrier…karnottApril 2, 2025 Read More
Publications of the Week Proliferation History and Transcription Factor Levels Drive Direct Conversion to Motor Neurons Wang, N., et al. | March 24, 2025 The sparse and stochastic nature of conversion has obscured our understanding of how transcription factors…karnottMarch 24, 2025 Read More